Unaudited condensed consolidated statements of operations - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues:
Product revenue, net	$ 47,575,000	$ 36,935,000	$ 93,670,000	$ 57,038,000
Collaboration revenue	601,000	0	1,230,000	0
Total revenues	48,176,000	36,935,000	94,900,000	57,038,000
Expenses:
Cost of sales	(17,407,000)	(10,868,000)	(33,051,000)	(18,373,000)
Research and development	(66,084,000)	(142,224,000)	(119,938,000)	(346,076,000)
Selling, general, and administrative	(63,401,000)	(54,414,000)	(120,392,000)	(90,252,000)
Loss from operations	(98,716,000)	(170,571,000)	(178,481,000)	(397,663,000)
Interest income	1,175,000	244,000	1,363,000	458,000
Other income (expenses), net	(40,392,000)	7,406,000	(42,988,000)	1,179,000
Loss before income tax and share of loss from equity method investment	(137,933,000)	(162,921,000)	(220,106,000)	(396,026,000)
Income tax expense	0	0	0	0
Share of loss from equity method investment	0	(403,000)	(221,000)	(208,000)
Net loss	(137,933,000)	(163,324,000)	(220,327,000)	(396,234,000)
Net loss attributable to ordinary shareholders - basic	(137,933,000)	(163,324,000)	(220,327,000)	(396,234,000)
Net loss attributable to ordinary shareholders - diluted	$ (137,933,000)	$ (163,324,000)	$ (220,327,000)	$ (396,234,000)
Loss per share/ADS - basic (in dollars per share)	$ (0.14)	$ (0.18)	$ (0.23)	$ (0.44)
Loss per share/ADS - diluted (in dollars per share)	$ (0.14)	$ (0.18)	$ (0.23)	$ (0.44)
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - basic (in shares)	957,684,820	930,455,310	956,603,250	907,231,320
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - diluted (in shares)	957,684,820	930,455,310	956,603,250	907,231,320
American Depositary Shares
Expenses:
Loss per share/ADS - basic (in dollars per share)	$ (1.44)	$ (1.76)	$ (2.30)	$ (4.37)
Loss per share/ADS - diluted (in dollars per share)	$ (1.44)	$ (1.76)	$ (2.30)	$ (4.37)
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - basic (in shares)	95,768,482	93,045,531	95,660,325	90,723,132
Weighted-average shares/ADSs used in calculating net loss per ordinary share/ADS - diluted (in shares)	95,768,482	93,045,531	95,660,325	90,723,132