X0508 4 2025-08-08 0001704292 Zai Lab Ltd ZLAB 0001662119 Amado Rafael C/O ZAI LAB LIMITED 314 MAIN STREET, 4TH FLOOR, SUITE 100 CAMBRIDGE MA 02142 true See Remarks true American Depositary Shares 2025-08-08 4 S 0 3000 35 D 42178 D Each American Depositary Share ("ADS") represents ten Ordinary Shares of the issuer. Our ADSs and Ordinary Shares are fully fungible. For purposes of this Form 4, we are reporting this in terms of ADSs. The transaction reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 22, 2024. President, Head of Global Oncology Research and Development /s/ Bruce Blefeld, Attorney-in-Fact 2025-08-12