SCHEDULE 13G 0001704131 XXXXXXXX LIVE Common Stock, par value $0.0001 02/04/2026 0001861123 Eikon Therapeutics, Inc. 282564103 230 Harriet Tubman Way Millbrae CA 94030 Rule 13d-1(c) Foresite Capital Fund IV, L.P. b DE 1960774.00 0.00 1960774.00 0.00 1960774.00 N 3.6 PN Note to Row 5: 1,960,774 shares, except that Foresite Capital Management IV, LLC ("FCM IV"), the general partner of Foresite Capital Fund IV, L.P. ("FCF IV"), may be deemed to have sole power to vote these shares, and James Tananbaum ("Tananbaum"), the managing member of FCM IV, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 1,960,774 shares, except that FCM IV, the general partner of FCF IV, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM IV, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 53,984,337 Common Stock outstanding of Eikon Therapeutics, Inc. (the "Issuer") as of February 4, 2026, as set forth in the Issuer's 424B4 filed with the Securities and Exchange Commission on February 5, 2026. Foresite Capital Management IV, LLC b DE 1960774.00 0.00 1960774.00 0.00 1960774.00 N 3.6 OO Note to Row 5: 1,960,774 shares, all of which are directly owned by FCF IV. FCM IV, the general partner of FCF IV, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM IV, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 1,960,774 shares, all of which are directly owned by FCF IV. FCM IV, the general partner of FCF IV, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM IV, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 53,984,337 Common Stock outstanding of the Issuer as of February 4, 2026, as set forth in the Issuer's 424B4 filed with the Securities and Exchange Commission on February 5, 2026. Foresite Capital Fund V, L.P. b DE 1353168.00 0.00 1353168.00 0.00 1353168.00 N 2.5 PN Note to Row 5: 1,353,168 shares, except that Foresite Capital Management V, LLC ("FCM V"), the general partner of Foresite Capital Fund V, L.P. ("FCF V"), may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 1,353,168 shares, except that FCM V, the general partner of FCF V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 53,984,337 Common Stock outstanding of the Issuer as of February 4, 2026, as set forth in the Issuer's 424B4 filed with the Securities and Exchange Commission on February 5, 2026. Foresite Capital Management V, LLC b DE 1353168.00 0.00 1353168.00 0.00 1353168.00 N 2.5 OO Note to Row 5: 1,353,168 shares, all of which are directly owned by FCF V. FCM V, the general partner of FCF V, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 1,353,168 shares, all of which are directly owned by FCF V. FCM V, the general partner of FCF V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM V, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 53,984,337 Common Stock outstanding of the Issuer as of February 4, 2026, as set forth in the Issuer's 424B4 filed with the Securities and Exchange Commission on February 5, 2026. Foresite Capital Opportunity Fund V, L.P. b DE 425852.00 0.00 425852.00 0.00 425852.00 N 0.8 PN Note to Row 5: 425,852 shares, except that Foresite Capital Opportunity Management V, LLC ("FCM Opp V"), the general partner of Foresite Capital Opportunity Fund V, L.P. ("FCF Opp V"), may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 425,852 shares, except that FCM Opp V, the general partner of FCF Opp V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 53,984,337 Common Stock outstanding of the Issuer as of February 4, 2026, as set forth in the Issuer's 424B4 filed with the Securities and Exchange Commission on February 5, 2026. Foresite Capital Opportunity Management V, LLC b DE 425852.00 0.00 425852.00 0.00 425852.00 N 0.8 OO Note to Row 5: 425,852 shares, all of which are directly owned by FCF Opp V. FCM Opp V, the general partner of FCF Opp V, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 425,852 shares, all of which are directly owned by FCF Opp V. FCM Opp V, the general partner of FCF Opp V, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM Opp V, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 53,984,337 Common Stock outstanding of the Issuer as of February 4, 2026, as set forth in the Issuer's 424B4 filed with the Securities and Exchange Commission on February 5, 2026. Foresite Capital VI-A, LLC b DE 408725.00 0.00 408725.00 0.00 408725.00 N 0.8 OO Note to Row 5: 408,725 shares, except that Foresite Capital VI-A Management, LLC ("FCM VI-A"), the managing member of Foresite Capital VI-A, LLC ("FC VI-A"), may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FC VI-A, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 408,725 shares, except that FCM VI-A, the managing member of FC VI-A, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM VI-A, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 53,984,337 Common Stock outstanding of the Issuer as of February 4, 2026, as set forth in the Issuer's 424B4 filed with the Securities and Exchange Commission on February 5, 2026. Foresite Capital VI-A Management, LLC b DE 408725.00 0.00 408725.00 0.00 408725.00 N 0.8 OO Note to Row 5: 408,725 shares, all of which are directly owned by FC VI-A. FCM VI-A, the managing member of FC VI-A, may be deemed to have sole power to vote these shares, and Tananbaum, the managing member of FCM VI-A, may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 408,725 shares, all of which are directly owned by FC VI-A. FCM VI-A, the managing member of FC VI-A, may be deemed to have sole power to dispose of these shares, and Tananbaum, the managing member of FCM VI-A, may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 53,984,337 Common Stock outstanding of the Issuer as of February 4, 2026, as set forth in the Issuer's 424B4 filed with the Securities and Exchange Commission on February 5, 2026. James B. Tananbaum b X1 4148519.00 0.00 4148519.00 0.00 4148519.00 N 7.7 IN Note to Row 5: 4,148,519 shares, of which 1,960,774 shares are directly owned by FCF IV, 1,353,168 shares are directly owned by FCF V, 425,852 shares are directly owned by FCF Opp V and 408,725 shares are directly owned by FC VI-A. Tananbaum is the managing member of each of FCM IV, which is the general partner of FCF IV, FCM V, which is the general partner of FCF V, FCM Opp V, which is the general partner of FCF Opp V and FCM VI-A, which is the managing member of FC VI-A. Tananbaum may be deemed to have sole power to vote these shares. Note to Row 6: See response to Row 5. Note to Row 7: 4,148,519 shares, of which 1,960,774 shares are directly owned by FCF IV, 1,353,168 shares are directly owned by FCF V, 425,852 shares are directly owned by FCF Opp V and 408,725 shares are directly owned by FC VI-A. Tananbaum is the managing member of each of FCM IV, which is the general partner of FCF IV, FCM V, which is the general partner of FCF V, FCM Opp V, which is the general partner of FCF Opp V and FCM VI-A, which is the managing member of FC VI-A. Tananbaum may be deemed to have sole power to dispose of these shares. Note to Row 8: See response to Row 7. Note to Row 11: This percentage is calculated based upon 53,984,337 Common Stock outstanding of the Issuer as of February 4, 2026, as set forth in the Issuer's 424B4 filed with the Securities and Exchange Commission on February 5, 2026. Eikon Therapeutics, Inc. 230 Harriet Tubman Way, Millbrae, CA 94030 This Schedule is filed by Foresite Capital Fund IV, L.P., a Delaware limited partnership, Foresite Capital Management IV, LLC, a Delaware limited liability company, Foresite Capital Fund V, L.P., a Delaware limited partnership, Foresite Capital Management V, LLC, a Delaware limited liability company, Foresite Capital Opportunity Fund V, L.P., a Delaware limited partnership, Foresite Capital Opportunity Management V, LLC, a Delaware limited liability company, Foresite Capital VI-A, LLC, a Delaware limited liability company, Foresite Capital VI-A Management, LLC, a Delaware limited liability company and James Tananbaum. The foregoing entities and individuals are collectively referred to as the "Reporting Persons." c/o Foresite Capital Management 9200 W. Sunset Boulevard, Suite 515 West Hollywood, CA 90069 See Row 4 of cover page for each Reporting Person. Y See Row 9 of cover page for each Reporting Person. See Row 11 of cover page for each Reporting Person. See Row 5 of cover page for each Reporting Person. See Row 6 of cover page for each Reporting Person. See Row 7 of cover page for each Reporting Person. See Row 8 of cover page for each Reporting Person. Y N Under certain circumstances set forth in the limited partnership agreements of FCF IV, FCF V and FCF Opp V and the limited liability company agreements of FC VI-A, FCM VI-A, FCM IV, FCM V and FCM Opp V, the partners or members, as the case may be, of each of such entities may be deemed to have the right to receive dividends from, or the proceeds from the sale of, shares of the Issuer directly or indirectly owned by each such entity of which they are a partner or member. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit A Agreement of Joint Filing The undersigned hereby agree that a single Schedule 13G (or any amendment thereto) relating to the Common Stock of the Issuer shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13G. Date: February 11, 2026 FORESITE CAPITAL FUND IV, L.P. By: FORESITE CAPITAL MANAGEMENT IV, LLC Its: General Partner By: /s/ James Tananbaum Name: James Tananbaum Title: Managing Member FORESITE CAPITAL MANAGEMENT IV, LLC By: /s/ James Tananbaum Name: James Tananbaum Title: Managing Member FORESITE CAPITAL FUND V, L.P. By: FORESITE CAPITAL MANAGEMENT V, LLC Its: General Partner By: /s/ James Tananbaum Name: James Tananbaum Title: Managing Member FORESITE CAPITAL MANAGEMENT V, LLC By: /s/ James Tananbaum Name: James Tananbaum Title: Managing Member FORESITE CAPITAL OPPORTUNITY FUND V, L.P. By: FORESITE CAPITAL OPPORTUNITY MANAGEMENT V, LLC Its: Managing Member By: /s/ James Tananbaum Name: James Tananbaum Title: Managing Member FORESITE CAPITAL OPPORTUNITY MANAGEMENT V, LLC By: /s/ James Tananbaum Name: James Tananbaum Title: Managing Member FORESITE CAPITAL VI-A, LLC By: FORESITE CAPITAL VI-A MANAGEMENT, LLC Its: Managing Member By: /s/ James Tananbaum Name: James Tananbaum Title: Managing Member FORESITE CAPITAL VI-A MANAGEMENT, LLC By: /s/ James Tananbaum Name: James Tananbaum Title: Managing Member JAMES TANANBAUM By: /s/ James Tananbaum Name: James Tananbaum Foresite Capital Fund IV, L.P. /s/ James Tananbaum 02/11/2026 Foresite Capital Management IV, LLC /s/ James Tananbaum 02/11/2026 Foresite Capital Fund V, L.P. /s/ James Tananbaum 02/11/2026 Foresite Capital Management V, LLC /s/ James Tananbaum 02/11/2026 Foresite Capital Opportunity Fund V, L.P. /s/ James Tananbaum 02/11/2026 Foresite Capital Opportunity Management V, LLC /s/ James Tananbaum 02/11/2026 Foresite Capital VI-A, LLC /s/ James Tananbaum 02/11/2026 Foresite Capital VI-A Management, LLC /s/ James Tananbaum 02/11/2026 James B. Tananbaum /s/ James Tananbaum 02/11/2026