X0306 4 2022-08-17 0001703647 Frequency Therapeutics, Inc. FREQ 0001439275 LeBel Carl C/O FREQUENCY THERAPEUTICS, INC. 75 HAYDEN AVE, SUITE 300 LEXINGTON MA 02421 1 Chief Development Officer Stock Option 2.14 2022-08-17 4 A 0 178937 A 2029-10-01 Common Stock 178937 178937 D Stock Option 14.00 2022-08-17 4 D 0 178937 D 2029-10-01 Common Stock 178937 0 D Stock Option 2.14 2022-08-17 4 A 0 75000 A 2031-01-14 Common Stock 75000 75000 D Stock Option 35.85 2022-08-17 4 D 0 75000 D 2031-01-14 Common Stock 75000 0 D Stock Option 2.14 2022-08-17 4 A 0 57500 A 2030-02-11 Common Stock 57500 57500 D Stock Option 25.05 2022-08-17 4 D 0 57500 D 2030-02-11 Common Stock 57500 0 D The option vests and becomes exercisable in equal monthly installments over a four year period commencing on November 2, 2019, and will be fully vested and exercisable on October 2, 2023. The transaction reported herein reflects a one-time stock option repricing that became effective on August 17, 2022 and is being reported in this manner solely to comply with the technical reporting requirements under Section 16(a) of the Securities Exchange Act of 1934, as amended. There have been no other changes to the terms of these options. The option vests and becomes exercisable in equal monthly installments over a four year period commencing on February 1, 2021, and will be fully vested and exercisable on January 1, 2025. The option vests and becomes exercisable in equal monthly installments over a four year period commencing on February 1, 2020, and will be fully vested and exercisable on January 1, 2024. /s/ James P. Abely, Attorney-in-Fact for Carl P. LeBel 2022-08-19