X0306 4 2022-02-14 0001703647 Frequency Therapeutics, Inc. FREQ 0001785299 Loose Christopher R. C/O FREQUENCY THERAPEUTICS, INC. 75 HAYDEN AVE, SUITE 300 LEXINGTON MA 02421 1 Chief Scientific Officer Common Stock 2022-02-14 4 M 0 15000 A 39484 D Common Stock 2022-02-15 4 S 0 863 4.331 D 38621 D Restricted Stock Unit 2022-02-14 4 M 0 15000 D Common Stock 15000 15000 D Each restricted stock unit represents a contingent right to receive one share of Issuer common stock. Includes 2,702 shares acquired under the Issuer's Employee Stock Purchase Plan on December 31, 2021. Represents a portion of the shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of the restricted stock units and does not represent discretionary trades by the Reporting Person. This transaction was executed in multiple trades through a broker-dealer at prices ranging from $4.28 to $4.40. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of shares sold at each price. The restricted stock units will vest as to 50% on February 14, 2022 and 50% on July 4, 2022. /s/ James P. Abely, Attorney-in-Fact for Christopher R. Loose 2022-02-16