X0306 4 2020-12-07 0001703647 Frequency Therapeutics, Inc. FREQ 0001785288 Lucchino David L. C/O FREQUENCY THERAPEUTICS, INC. 19 PRESIDENTIAL WAY, 2ND FLOOR WOBURN MA 01801 1 1 President and CEO Common Stock 2020-12-07 4 M 0 4666 .61 A 328466 D Common Stock 2020-12-07 4 S 0 4666 30.0183 D 323800 D Common Stock 2020-12-08 4 M 0 8848 .61 A 332648 D Common Stock 2020-12-08 4 S 0 4050 30.96 D 328598 D Common Stock 2020-12-08 4 S 0 4798 31.52 D 323800 D Stock Option .61 2020-12-07 4 M 0 4666 0 D 2027-06-28 Common Stock 4666 46200 D Stock Option .61 2020-12-08 4 M 0 8848 0 D 2027-06-28 Common Stock 8848 37352 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 15, 2020. This transaction was executed in multiple trades through a broker-dealer at prices ranging from $30 to $30.215. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price. This transaction was executed in multiple trades through a broker-dealer at prices ranging from $30.01 to $31. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price. This transaction was executed in multiple trades through a broker-dealer at prices ranging from $31.015 to $31.595. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price. The option vests and becomes exercisable in equal monthly installments over a four year period commencing on February 1, 2017, and will be fully vested and exercisable on January 1, 2021. /s/ Michael D. Bookman, Attorney-in-Fact for David L. Lucchino 2020-12-09