X0306 4 2020-05-20 0001703647 Frequency Therapeutics, Inc. FREQ 0001785299 Loose Christopher R. C/O FREQUENCY THERAPEUTICS, INC. 19 PRESIDENTIAL WAY, 2ND FLOOR WOBURN MA 01801 1 Chief Scientific Officer Common Stock 2020-05-20 4 S 0 2668 18.8164 D 189114 D Common Stock 2020-05-20 4 S 0 1832 19.3277 D 187282 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019. This transaction was executed in multiple trades through a broker-dealer at prices ranging from $18.23 to $19.22. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price. This transaction was executed in multiple trades through a broker-dealer at prices ranging from $19.23 to $19.42. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price. /s/ Michael D. Bookman, Attorney-in-Fact for Christopher R. Loose 2020-05-22