Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Cash flows from operating activities:
Net loss	$ (77,540)	$ (70,638)
Cash flows from operating activities:
Depreciation of property and equipment	6,603	5,810
Amortization and impairment of intangible assets	34,763	5,314
Amortization of operating lease right-of-use assets	3,437	3,252
Stock-based compensation	35,191	31,873
Fair value gain on contingent consideration	(30,920)	0
Other	(8,193)	(4,429)
Changes in operating assets and liabilities:
Research fees and grants receivable	(34,434)	(24,269)
Accrued royalties receivable	0	9,260
Income taxes payable (receivable)	(5,953)	22,884
Accounts payable and accrued liabilities	(130)	(2,827)
Deferred revenue	(12,782)	(4,870)
Accrued royalties payable	0	(16,253)
Deferred grant income	19,757	25,566
Other assets	(1,473)	(4,833)
Net cash used in operating activities	(71,674)	(24,160)
Cash flows from investing activities:
Purchases of property and equipment	(44,250)	(42,185)
Purchase of marketable securities	(426,007)	(528,891)
Proceeds from marketable securities	539,385	422,814
Receipt of grant funding	19,750	7,693
Long-term investments and other assets	3,950	(36,757)
Investment in equity accounted investees	(10,820)	(6,673)
Net cash provided by (used in) investing activities	82,008	(183,999)
Cash flows from financing activities:
Payment of liability for in-licensing agreement and other	(368)	(863)
Proceeds from long-term liabilities	4,497	0
Proceeds from exercise of stock options	1,353	824
Net cash provided by (used in) financing activities	5,482	(39)
Effect of exchange rate changes on cash and cash equivalents	(824)	584
Increase (decrease) in cash and cash equivalents	14,992	(207,614)
Cash and cash equivalents and restricted cash, beginning of period	160,610	414,651
Cash and cash equivalents and restricted cash, end of period	175,602	207,037
Restricted cash included in other assets	2,290	2,290
Total cash, cash equivalents, and restricted cash shown on the balance sheet	173,312	204,747
Supplemental disclosure of non-cash investing and financing activities
Property and equipment in accounts payable	15,944	11,718
Right-of-use assets obtained in exchange for operating lease obligation	$ 452	$ 2,945