Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net income	$ 161,788	$ 114,898
Cash flows from operating activities:
Depreciation of property and equipment	3,681	1,897
Amortization of intangible assets	5,213	4,930
Amortization of operating lease right-of-use assets	2,120	1,354
Stock-based compensation	24,404	13,900
Other	(298)	337
Changes in operating assets and liabilities:
Accounts and accrued research fees receivable	(6,963)	(28,339)
Accrued royalties receivable	106,583	172,768
Income taxes payable	52,251	(30,330)
Accounts payable and accrued liabilities	(1,882)	(3,640)
Deferred revenue	(2,979)	4,848
Accrued royalties payable	28,049	(3,623)
Deferred grant revenue	5,406	22,349
Other assets	(4,139)	(4,121)
Net cash provided by operating activities	373,234	267,228
Cash flows from investing activities:
Purchases of property and equipment	(45,817)	(40,448)
Purchase of marketable securities	(134,306)
Proceeds from marketable securities	145,808
Receipt of grant funding	8,098	4,520
Long-term investments and other assets	(11,657)	(5,034)
Investment in and loans to equity accounted investees	(15,694)	(20,510)
Net cash used in investing activities	(53,568)	(61,472)
Cash flows from financing activities:
Repayment of long-term debt and contingent consideration	(73)	(4,373)
Proceeds from debt and exercise of stock options	2,175	2,755
Payment of liability for in-licensing agreement	(4,060)	(5,000)
Net cash used in financing activities	(1,958)	(6,618)
Effect of exchange rate changes on cash and cash equivalents	(1,411)	(683)
Increase in cash and cash equivalents	316,297	198,455
Cash and cash equivalents and restricted cash, beginning of period	501,142	594,116
Cash and cash equivalents and restricted cash, end of period	817,439	792,571
Restricted cash included in other assets	(1,824)
Total cash, cash equivalents and restricted cash shown in the statement of cash flows	815,615	792,571
Supplemental disclosure of non-cash investing and financing activities
Property plant and equipment in accounts payable	2,146
Right-of-use assets obtained in exchange for operating lease obligation	$ (796)	$ 29,573