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INCOME TAXES (Tables)
12 Months Ended
Dec. 31, 2021
Income Tax Disclosure [Abstract]  
Schedule of Income before Income Tax Income (loss) before income tax expense consists of the following:
December 31,

20212020
Domestic$(125,328)$(66,992)
Foreign(268)(262)
Total loss before income taxes
$(125,596)$(67,254)
Schedule of Income Tax Rate Reconciliation A reconciliation of income taxes computed using the U.S. federal statutory rate to that reflected in operations as of December 31, 2021 and 2020, respectively, is as follows:

December 31,

2021

2020
U.S. federal statutory income tax rate
21.0 %

21.0 %
State and local taxes, net of federal benefit    
4.1 %

3.4 %
Permanent differences
(0.1)%

0.0 %
Stock compensation(0.4)%(0.8)%
Research and development credits        
2.6 %

2.2 %
Change in valuation allowance    
(27.2)%

(26.5)%
Other
0.0 %0.7 %
Effective income tax rate    
0.0 %

0.0 %
Schedule of Deferred Tax Assets The tax effects of temporary differences that gave rise to significant portions of the deferred tax assets were as follows:
 Tax year ended December 31,

20212020
Deferred tax assets (liabilities):  
Net operating loss carryforwards$52,568 $24,059 
Research and development tax credits5,439 2,477 
Operating lease liabilities7,172 2,147 
Accruals and other1,251 680 
Stock-based compensation3,835 1,434 
Total deferred tax assets70,265 30,797 
Valuation Allowance(63,014)(28,709)
Subtotal7,251 2,088 
Right-of-use assets(7,236)(2,063)
Net fixed assets(15)(25)
Net deferred tax assets$— $—