CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
Cash flows from operating activities:
Net loss	$ (28,385)	$ (73,186)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	329	740
Non-cash lease cost	720	446
Impairment of long-term asset	5,306	635
Share-based compensation	5,935	6,626
Unrealized foreign currency transaction (gain) loss	0	8
Accretion of discount on marketable securities	0	13
Change in fair value of derivative liability	0	(776)
Non-cash interest expense associated with the sale of future royalties	0	2,605
Loss on extinguishment of liability related to the sale of future royalties	0	3,581
Changes in operating assets and liabilities:
Other receivables	(1,905)	1,678
Prepaid expenses and other current assets	(2,029)	7,133
Other assets	0	(2)
Accounts payable	486	1,483
Accrued expenses and other current liabilities	(2,410)	(6,257)
Deferred revenue, current and non-current	5,091	3,525
Other long-term liabilities	(35)	(31)
Operating lease liability	(816)	(434)
Income tax	2,211	0
Net cash used in operating activities	(15,502)	(52,213)
Cash flows from investing activities:
Purchases of marketable securities	0	(26,970)
Proceeds from maturities of marketable securities	0	60,777
Net cash provided by (used in) investing activities	0	33,807
Cash flows from financing activities:
Repayment of liability related to the sale of future royalties	0	(54,485)
Proceeds from the issuance of common stock, net of issuance costs	220	10,334
Proceeds from stock option exercises	0	419
Net cash provided by financing activities	220	(43,732)
Net decrease in cash and cash equivalents:	(15,282)	(62,138)
Cash, cash equivalents and restricted cash at beginning of period	109,107	112,584
Cash, cash equivalents and restricted cash at end of period	$ 93,825	$ 50,446