Restructuring - Schedule of restructuring related charges (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Restructuring Cost and Reserve [Line Items]
Restructuring	$ 0	$ (152)	$ 0	$ 11,697
Research and development
Restructuring Cost and Reserve [Line Items]
Restructuring		(53)		4,360
General and administrative
Restructuring Cost and Reserve [Line Items]
Restructuring		(99)		7,337
Severance and other employee costs
Restructuring Cost and Reserve [Line Items]
Restructuring		(105)		8,552
Severance and other employee costs | Research and development
Restructuring Cost and Reserve [Line Items]
Restructuring		(53)		3,872
Severance and other employee costs | General and administrative
Restructuring Cost and Reserve [Line Items]
Restructuring		(52)		4,680
Lease impairment
Restructuring Cost and Reserve [Line Items]
Restructuring		0		635
Lease impairment | Research and development
Restructuring Cost and Reserve [Line Items]
Restructuring		0		372
Lease impairment | General and administrative
Restructuring Cost and Reserve [Line Items]
Restructuring		0		263
Other
Restructuring Cost and Reserve [Line Items]
Restructuring		(47)		2,510
Other | Research and development
Restructuring Cost and Reserve [Line Items]
Restructuring		0		116
Other | General and administrative
Restructuring Cost and Reserve [Line Items]
Restructuring		$ (47)		$ 2,394