Common Stock - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended	3 Months Ended		9 Months Ended
	Sep. 21, 2022	Jun. 30, 2021	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Dec. 31, 2022	Mar. 29, 2021
Class Of Stock [Line Items]
Issuance of stock, value			$ 220	$ 6,128	$ 220	$ 10,331
Proceeds from sale of common stock to related party					220	$ 10,334
Common Stock, Value, Issued, Total			$ 53		$ 53		$ 52
Common Stock [Member]
Class Of Stock [Line Items]
Issuance of stock, shares			144,476	3,226,859	144,476	3,964,478
Issuance of stock, value				$ 4		$ 5
Pfizer Inc Member
Class Of Stock [Line Items]
Issuance of stock, shares		2,362,348
Issuance of stock, value		$ 27,500
Gsk Spa [Member]
Class Of Stock [Line Items]
Issuance of stock, shares	7,450,000
Issuance of stock, value	$ 10,300
Sales Agreement [Member]
Class Of Stock [Line Items]
Gross proceeds from issuance of common stock					$ 200
Issuance of stock, shares			144,476		144,476
Share price			$ 1.58		$ 1.58
Pfizer Purchase Agreement [Member]
Class Of Stock [Line Items]
Issuance of stock, value		$ 12,500
Pfizer Purchase Agreement [Member] | Pfizer Inc Member
Class Of Stock [Line Items]
Issuance of stock, shares		2,362,348
Share price		$ 16.93
Proceeds from sale of common stock to related party		$ 40,000
GSK License Agreement [Member]
Class Of Stock [Line Items]
Issuance of stock, shares	7,450,000
Issuance of stock, value	$ 1,300
Share price	$ 1.20805
Common Stock, Value, Issued, Total	$ 9,000
At-The-Market Offering Program [Member] | Cantor Fitzgerald & Co [Member] | Maximum [Member]
Class Of Stock [Line Items]
Authorized offering value								$ 300,000
Common stock available for issuance								$ 75,000