Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Payables and Accruals [Abstract]
Accrued external research and development expenses	$ 2,221	$ 1,823
Accrued payroll and related expenses	5,258	5,797
Accrued professional fees	1,173	696
Accrued restructuring expenses	39	448
Accrued other	171	209
Total Accrued expenses and other current liabilities	$ 8,862	$ 8,973