Income Taxes - Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Income Tax Disclosure [Abstract]
Net operating loss carryforwards	$ 78,619	$ 83,849
Research and development tax credit carryforwards	14,294	12,375
Capitalized research and development expenses	11,613	0
Other	10,264	6,220
Total deferred tax assets	114,790	102,444
Valuation allowance	(114,790)	(102,444)	$ (75,039)
Net deferred tax assets	$ 0	$ 0