Equity - Additional Information (Detail) - USD ($)		1 Months Ended		9 Months Ended	12 Months Ended
	Sep. 21, 2022	Jun. 30, 2022	Feb. 28, 2021	Sep. 30, 2022	Dec. 31, 2022	Dec. 31, 2021	Aug. 17, 2021	Jun. 30, 2021	Mar. 11, 2021
Class Of Stock [Line Items]
Preferred stock, shares authorized					10,000,000	10,000,000
Issuance of common stock and preferred stock net of offering costs and issuance costs					$ 14,234,000	$ 7,831,000
Common Stock, Shares Authorized					120,000,000	120,000,000
Common Stock, Value, Issued					$ 52,000	$ 32,000
Maximum [Member]
Class Of Stock [Line Items]
Common Stock, Shares Authorized							120,000,000
Minimum [Member]
Class Of Stock [Line Items]
Common Stock, Shares Authorized							60,000,000
Pfizer Inc [Member]
Class Of Stock [Line Items]
Issuance of stock, shares			2,362,348
Issuance of common stock and preferred stock net of offering costs and issuance costs			$ 27,500,000
GSK SPA [Member]
Class Of Stock [Line Items]
Issuance of stock, shares	7,450,000
Issuance of common stock and preferred stock net of offering costs and issuance costs	$ 10,300,000
GSK License Agreement [Member]
Class Of Stock [Line Items]
Issuance of stock, shares	7,450,000
Share price	$ 1.20805
Issuance of common stock and preferred stock net of offering costs and issuance costs	$ 1,300,000
Common Stock, Value, Issued	$ 9,000,000.0
Pfizer Purchase Agreement [Member]
Class Of Stock [Line Items]
Issuance of common stock and preferred stock net of offering costs and issuance costs			$ 12,500
Pfizer Purchase Agreement [Member] | Pfizer Inc [Member]
Class Of Stock [Line Items]
Issuance of stock, shares		2,362,348
Share price								$ 16.93
Proceeds from sale of common stock to related party		$ 40,000,000.0
At-The-Market Offering Program [Member]
Class Of Stock [Line Items]
Issuance of stock, shares					5,963,294
Share price					$ 2.46
Gross proceeds from issuance of common and preferred stock					$ 14,700,000
At-The-Market Offering Program [Member] | Cantor Fitzgerald & Co [Member] | Maximum [Member]
Class Of Stock [Line Items]
Authorized offering value									$ 300,000,000.0
Common stock available for issuance									$ 75,000,000.0
Series A Convertible Preferred Stock [Member]
Class Of Stock [Line Items]
Issuance of stock, shares					2,220
Preferred stock, shares authorized					10,000,000
Number of shares issuable upon conversion					1,000
Maximum percentage of common stock holding upon conversion of preferred stock					9.99%
Preferred stock, liquidation per share					$ 0.001
Voting rights					no
Series B Convertible Preferred Stock [Member]
Class Of Stock [Line Items]
Issuance of stock, shares		938	62		1,000
Preferred stock, shares authorized					10,000,000
Number of shares issuable upon conversion		938,000	62,000		1,000
Maximum percentage of common stock holding upon conversion of preferred stock					9.99%
Preferred stock, liquidation per share					$ 0.001
Voting rights					no
Series C Convertible Preferred Stock [Member]
Class Of Stock [Line Items]
Issuance of stock, shares		2,214			3,333
Preferred stock, shares authorized					10,000,000
Number of shares issuable upon conversion			73,000	2,214,000	1,000
Maximum percentage of common stock holding upon conversion of preferred stock					9.99%
Preferred stock, liquidation per share					$ 0.001
Voting rights					no
Preferred stock, conversion basis			73
Series D Preferred Stock [Member]
Class Of Stock [Line Items]
Issuance of stock, shares					3,215,000
Preferred stock, shares authorized					10,000,000
Number of shares issuable upon conversion		942,000		2,273,000
Maximum percentage of common stock holding upon conversion of preferred stock					9.99%
Preferred stock, liquidation per share					$ 0.001
Voting rights					no
Preferred stock, conversion basis		942,000		2,273,000	The shares of Series D Preferred Stock are convertible on a one-to-one basis into shares of common stock at any time at the option of the holder, provided that the holder will be prohibited from converting the Series D Preferred Stock into shares of common stock if, as a result of such conversion, the holder, together with its affiliates, would own more than 9.99% of the total number of shares of common stock then issued and outstanding, subject to certain exceptions.
Common Stock [Member]
Class Of Stock [Line Items]
Issuance of stock, shares					5,963,294	475,469
Issuance of common stock and preferred stock net of offering costs and issuance costs					$ 7,000	$ 1,000