Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Accrued external research and development expenses	$ 1,823	$ 6,315
Accrued payroll and related expenses	5,797	5,884
Accrued professional fees	696	909
Accrued restructuring expenses	448	0
Accrued other	209	1,242
Accrued expenses and other current liabilities	$ 8,973	$ 14,350