CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Revenues:
Grant revenue	$ 4,930	$ 15,186
Collaboration revenue	$ 48,579	$ 3,070
Type of Revenue [Extensible List]	License [Member]	License [Member]
Total revenues	$ 53,509	$ 18,256
Operating expenses:
Research and development	47,593	64,526
General and administrative	36,483	41,701
Restructuring Charges	11,630	0
Total operating expenses	95,706	106,227
Loss from operations	(42,197)	(87,971)
Other income (expense):
Interest income	1,106	346
Other income (expense), net	(55)	(395)
Interest expense related to the sale of future royalties	(2,605)	(1,940)
Loss on extinguishment of liability related to the sale of future royalties	(3,581)	0
Change in fair value of derivative liability	917	204
Total other income (expense), net	(4,218)	(1,785)
Net loss	$ (46,415)	$ (89,756)
Net loss per share attributable to common stockholders, basic	$ (1.23)	$ (2.91)
Net loss per share attributable to common stockholders, diluted	$ (1.23)	$ (2.91)
Weighted average common shares outstanding, basic	37,585,075	30,895,756
Weighted Average Number of Shares Outstanding, Diluted	37,585,075	30,895,756
Comprehensive loss:
Net loss	$ (46,415)	$ (89,756)
Other comprehensive gain (loss):
Unrealized gain (loss) on marketable securities	2	5
Unrealized gain (loss) on available-for-sale securities	2	5
Total comprehensive loss	$ (46,413)	$ (89,751)