Restructuring - Restructuring charges (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Restructuring Cost and Reserve [Line Items]
Severance and other employee costs	$ (105)		$ 8,552
Lease impairment	0		635
Other	(47)		2,510
Total restructuring charges	(152)	$ 0	11,697	$ 0
Research and Development Expense [Member]
Restructuring Cost and Reserve [Line Items]
Severance and other employee costs	(53)		3,872
Lease impairment	0		372
Other	0		116
Total restructuring charges	(53)		4,360
General and Administrative Expense [Member]
Restructuring Cost and Reserve [Line Items]
Severance and other employee costs	(52)		4,680
Lease impairment	0		263
Other	(47)		2,394
Total restructuring charges	$ (99)		$ 7,337