Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Accrued external research and development expenses	$ 1,219	$ 6,315
Accrued restructuring expenses	967	0
Accrued payroll and related expenses	4,860	5,884
Accrued professional fees	836	909
Accrued other	211	1,242
Total Accrued expenses and other current liabilities	$ 8,093	$ 14,350