Nature of the Business and Basis of Presentation - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Nov. 07, 2022	Dec. 31, 2021
Subsequent Event [Line Items]
Net loss	$ 11,700	$ 22,500	$ 73,200	$ 60,500
Accumulated deficit	440,649		440,649			$ 367,463
Common stock to be issued	$ 43		$ 43			$ 32
Subsequent Events
Subsequent Event [Line Items]
Milestone payment					$ 225,000
GSK License Agreement [Member] | GSK [Member] | Subsequent Events
Subsequent Event [Line Items]
Milestone payment					66,000
GGL [Member] | Subsequent Events
Subsequent Event [Line Items]
Common stock to be issued					$ 9,000