Restructuring - Restructuring charges (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Restructuring Cost and Reserve [Line Items]
Severance and other employee costs	$ 8,657		$ 8,657
Lease impairment	635		635
Other	2,557		2,557
Restructuring Charges, Total	11,849	$ 0	11,849	$ 0
Research and Development Expense [Member]
Restructuring Cost and Reserve [Line Items]
Severance and other employee costs	3,925		3,925
Lease impairment	372		372
Other	116		116
Restructuring Charges, Total	4,413		4,413
General and Administrative Expense [Member]
Restructuring Cost and Reserve [Line Items]
Severance and other employee costs	4,732		4,732
Lease impairment	263		263
Other	2,441		2,441
Restructuring Charges, Total	$ 7,436		$ 7,436