CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Cash flows from operating activities:
Net loss	$ (28,682)	$ (18,572)	$ (61,511)	$ (37,995)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization			483	307
Non-cash lease cost			218	402
Share-based compensation	1,317	2,163	4,520	4,172
Unrealized foreign currency transaction (gain) loss			7	10
Accretion of discount on marketable securities			13	124
Change in fair value of derivative liability			(802)	0	$ (200)
Non-cash interest expense associated with the sale of future royalties			2,605	0
Loss on extinguishment of liability related to the sale of future royalties	3,581	0	3,581	0
Changes in operating assets and liabilities:
Other receivables			721	3,479
Prepaid expenses and other current assets			3,646	1,258
Tax incentive receivables			333	800
Other assets			905	(8)
Accounts payable			612	478
Accrued expenses and other current liabilities			(5,839)	(3,314)
Deferred revenue, current and non-current			(393)	(1,356)
Other long-term liabilities			(21)	(19)
Operating lease liability			(334)	(400)
Net cash used in operating activities			(51,256)	(32,046)
Cash flows from investing activities:
Purchases of marketable securities			(26,970)	(12,578)
Proceeds from maturities of marketable securities			60,777	26,500
Write-off of property and equipment			129	0
Net cash provided by (used in) investing activities			33,936	13,922
Cash flows from financing activities:
Repayment of liability related to the sale of future royalties			(54,485)	0
Proceeds from the issuance of common stock, net of issuance costs			4,203	4,253
Payment of offering and financing costs			0	(146)
Proceeds from stock option exercises			419	370
Net cash provided by financing activities			(49,863)	4,477
Net increase (decrease) in cash and cash equivalents			(67,183)	(13,647)
Cash, cash equivalents and restricted cash at beginning of period			112,584	85,209	85,209
Cash, cash equivalents and restricted cash at end of period	$ 45,401	$ 71,562	45,401	71,562	$ 112,584
Supplemental disclosure of non-cash activities:
Offering and financing costs in accounts payable and accruals			$ 0	$ 80