Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Accrued external research and development expenses	$ 2,535	$ 6,315
Accrued restructuring expenses	2,088	0
Accrued payroll and related expenses	2,207	5,884
Accrued professional fees	1,165	909
Accrued other	516	1,242
Total Accrued expenses and other current liabilities	$ 8,511	$ 14,350