Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Accrued external research and development expenses	$ 4,147	$ 6,315
Accrued payroll and related expenses	2,397	5,884
Accrued professional fees	1,452	909
Accrued other	1,064	1,242
Total Accrued expenses and other current liabilities	$ 9,060	$ 14,350