Share-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2022

Share Based Compensation Arrangement By Share Based Payment Award [Line Items]

Summary of Stock Option Activity

The following table summarizes stock option activity under all equity plans (excluding RSUs) during the three months ended March 31, 2022:

	Number of Shares			Weighted Average Exercise Price		Weighted Average Contractual Term		Aggregate Intrinsic Value
						(in years)		(in thousands)
Outstanding as of December 31, 2021		4,890,716		$	11.75		7.62	$	24,263
Granted		952,604			11.15		—		—
Exercised		(17,616	)		10.72		—		—
Forfeited or cancelled		(50,636	)		14.80		—
Outstanding as of March 31, 2022		5,775,068		$	11.63		7.61	$	3,951
Outstanding as of March 31, 2022 - vested and    expected to vest		5,775,068		$	11.63		7.61	$	3,951
Exercisable at March 31, 2022		2,868,263		$	9.47		6.29	$	3,684

Summary of Share-Based Compensation Expense

The Company recorded share-based compensation expense related to incentive stock options, nonqualified stock options, stock grants, and stock-based awards in the following expense categories of its consolidated statements of operations and comprehensive loss (in thousands):

	Three Months Ended March 31,
	2022		2021
Research and development expenses	$	1,363	$	840
General and administrative expenses		1,840		1,169
Total	$	3,203	$	2,009

Restricted Stock Units (RSUs) [Member]

Share Based Compensation Arrangement By Share Based Payment Award [Line Items]

Summary of Activity of Options and RSUs of Performance-Based Options

The following table summarizes RSU activity under all equity plans during the three months ended March 31, 2022:

	Number of RSU Shares			Weighted Average Grant Date Fair Value
Outstanding as of December 31, 2021		513,690			17.08
Granted		657,757			11.14
Vested and released		—			—
Forfeited or cancelled		(7,800	)		15.51
Outstanding as of March 31, 2022		1,163,647			13.73