Income Taxes - Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax Disclosure [Abstract]
Net operating loss carryforwards	$ 83,849	$ 63,612
Research and development tax credit carryforwards	12,375	8,024
Other	6,220	3,403
Total deferred tax assets	102,444	75,039
Valuation allowance	(102,444)	(75,039)	$ (51,980)
Net deferred tax assets	$ 0	$ 0