Equity - Additional Information (Detail) - USD ($)					1 Months Ended	6 Months Ended	12 Months Ended
	Oct. 01, 2020	Sep. 15, 2020	Sep. 09, 2020	Mar. 05, 2020	Feb. 28, 2021	Jun. 30, 2021	Dec. 31, 2021	Dec. 31, 2020	Mar. 11, 2021	Nov. 13, 2020	Dec. 11, 2018
Class Of Stock [Line Items]
Preferred stock, shares authorized							10,000,000	10,000,000
Issuance of common stock and preferred stock net of offering costs and issuance costs							$ 7,831,000	$ 77,929,000
Proceeds from sale of common stock to related party							7,831,000	13,166,000
Pfizer Inc [Member]
Class Of Stock [Line Items]
Issuance of stock, shares					2,362,348
Issuance of common stock and preferred stock net of offering costs and issuance costs					$ 27,500
Pfizer Purchase Agreement [Member]
Class Of Stock [Line Items]
Issuance of common stock and preferred stock net of offering costs and issuance costs					$ 12,500
Pfizer Purchase Agreement [Member] | Pfizer Inc [Member]
Class Of Stock [Line Items]
Issuance of stock, shares						2,362,348
Share price						$ 16.93
Proceeds from sale of common stock to related party						$ 40,000.0
At-The-Market Offering Program [Member]
Class Of Stock [Line Items]
Proceeds from sale of common stock to related party							8,100
At-The-Market Offering Program [Member] | Cantor Fitzgerald & Co [Member]
Class Of Stock [Line Items]
Common stock available for issuance							344,205
Proceeds from sale of common stock to related party							$ 3,700,000
At-The-Market Offering Program [Member] | Sales Agreement [Member]
Class Of Stock [Line Items]
Common stock available for issuance										$ 34,000,000.0
At-The-Market Offering Program [Member] | Sales Agreement [Member] | Cantor Fitzgerald & Co [Member]
Class Of Stock [Line Items]
Gross proceeds from issuance of common stock			$ 15,400,000
Common stock value remaining available for issuance			$ 34,600,000							$ 34,000,000.0
At-The-Market Offering Program [Member] | Sales Agreement [Member] | Cantor Fitzgerald & Co [Member] | Maximum [Member]
Class Of Stock [Line Items]
Authorized offering value									$ 300,000,000.0		$ 200,000,000.0
Common stock available for issuance									$ 75,000,000.0		$ 50,000,000.0
Underwritten Public Offering Member
Class Of Stock [Line Items]
Gross proceeds from issuance of common and preferred stock		$ 80,000,000.0
Net proceeds from issuance of common and preferred stock		$ 74,700,000
Series A Convertible Preferred Stock [Member]
Class Of Stock [Line Items]
Issuance of stock, shares							2,220
Preferred stock, shares authorized							10,000,000
Number of shares issuable upon conversion							1,000
Maximum percentage of common stock holding upon conversion of preferred stock							9.99%
Preferred stock, liquidation per share							$ 0.001
Voting rights							no
Share price				$ 8.98
Series B Convertible Preferred Stock [Member]
Class Of Stock [Line Items]
Issuance of stock, shares							1,000
Preferred stock, shares authorized							10,000,000
Number of shares issuable upon conversion					62,000		1,000
Maximum percentage of common stock holding upon conversion of preferred stock							9.99%
Preferred stock, liquidation per share							$ 0.001
Voting rights							no
Preferred stock, conversion basis					62
Series C Convertible Preferred Stock [Member]
Class Of Stock [Line Items]
Issuance of stock, shares							3,333
Preferred stock, shares authorized							10,000,000
Number of shares issuable upon conversion					73,000		1,000
Maximum percentage of common stock holding upon conversion of preferred stock							9.99%
Preferred stock, liquidation per share							$ 0.001
Voting rights							no
Preferred stock, conversion basis					73
Series D Preferred Stock [Member]
Class Of Stock [Line Items]
Issuance of stock, shares							3,215,000
Preferred stock, shares authorized							10,000,000
Maximum percentage of common stock holding upon conversion of preferred stock							9.99%
Preferred stock, liquidation per share							$ 0.001
Voting rights							no
Preferred stock, conversion basis							The shares of Series D Preferred Stock are convertible on a one-to-one basis into shares of common stock at any time at the option of the holder, provided that the holder will be prohibited from converting the Series D Preferred Stock into shares of common stock if, as a result of such conversion, the holder, together with its affiliates, would own more than 9.99% of the total number of shares of common stock then issued and outstanding, subject to certain exceptions.
Issuance of common stock and preferred stock net of offering costs and issuance costs								$ 30,221,000
Series D Preferred Stock [Member] | Underwritten Public Offering Member
Class Of Stock [Line Items]
Issuance of stock, shares		3,215,000
Share price		$ 10.00
Common Stock [Member]
Class Of Stock [Line Items]
Issuance of stock, shares				1,046,249			475,469	8,025,119
Issuance of common stock and preferred stock net of offering costs and issuance costs							$ 1,000	$ 8,000
Common Stock [Member] | At-The-Market Offering Program [Member]
Class Of Stock [Line Items]
Issuance of stock, shares							475,469
Share price							$ 16.98
Common Stock [Member] | Underwritten Public Offering Member
Class Of Stock [Line Items]
Issuance of stock, shares	1,200,000	4,785,000
Share price	$ 10.00	$ 10.00
Proceeds from sale of common stock to related party	$ 11,200,000