Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Payables and Accruals [Abstract]
Accrued external research and development expenses	$ 6,315	$ 7,035
Accrued payroll and related expenses	5,884	3,918
Accrued professional fees	909	1,066
Accrued other	1,242	222
Accrued expenses and other current liabilities	$ 14,350	$ 12,241