Leases - Additional Information (Detail)				1 Months Ended	3 Months Ended	12 Months Ended
	May 04, 2020	Dec. 16, 2019 USD ($) ft² Option	Jan. 17, 2018 USD ($) ft²	Aug. 31, 2015 USD ($)	Dec. 30, 2018 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Lessee Lease Description [Line Items]
Finance Lease, Liability, Statement of Financial Position [Extensible Enumeration]						Property, Plant and Equipment, Net	Property, Plant and Equipment, Net
Meiji License Agreement [Member]
Lessee Lease Description [Line Items]
Embedded finance leases fixed assets related payments					$ 1,600,000
Finance lease liability						$ 0	$ 0
Office Space [Member]
Lessee Lease Description [Line Items]
Operating lease beginning date				2016-01
Operating lease expiration date				2020-12
Operating lease, existence of option to extend				true
Security deposit				$ 200,000
Annual rent escalations and tenant incentives				700,000
Amount reimbursed				$ 300,000
Office Space [Member] | Lease Agreements [Member] | Cambridge, Massachusetts [Member] | U.S. REIF Central Plaza Massachusetts, LLC [Member]
Lessee Lease Description [Line Items]
Operating lease beginning date	2020-08	2020-06
Operating lease expiration date	2027-07	2027-05
Operating lease, existence of option to extend	true	true
Area of office space | ft²		7,800	7,800
Term of lease			7 years
Lease expiration term			2025-12
Leasehold improvements receivable from the Landlord		$ 600	$ 400,000
Number of renewal options | Option		2
Lease renewal term		5 years
Operating lease, option to extend						the Company has two consecutive options to extend the Lease Term for an additional period of five years (the “Option Terms”), subject to certain conditions, upon notice to the Landlord.
Operating leases annual base rent initial		$ 600,000
Operating leases annual base rent final		$ 700,000
Operating lease percentage of annual base rent		100.00%