SCHEDULE 13G 0001699737 XXXXXXXX LIVE Common Stock, $0.00001 par value per share 02/09/2026 0001778922 SPYGLASS PHARMA, INC. 85220G109 27061 Aliso Creek Rd., Suite 100 Aliso Viejo CA 92656 Rule 13d-1(c) Samsara BioCapital, L.P. b DE 0.00 1484953.00 0.00 1484953.00 1484953.00 4.5 PN Samsara BioCapital GP, LLC b DE 1484953.00 0.00 1484953.00 0.00 1484953.00 4.5 OO Samsara Opportunity Fund, L.P. b DE 0.00 625000.00 0.00 625000.00 625000.00 1.9 PN Samsara Opportunity Fund GP, LLC b DE 0.00 625000.00 0.00 625000.00 625000.00 1.9 OO Srinivas Akkaraju b X1 0.00 2109953.00 0.00 2109953.00 2109953.00 6.3 IN SPYGLASS PHARMA, INC. 27061 Aliso Creek Rd., Suite 100, Aliso Viejo, CA, 92656. The names of the persons filing this report (collectively, the "Reporting Persons") are: Samsara BioCapital, L.P. ("Samsara LP") Samsara BioCapital GP, LLC ("Samsara GP") Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund") Samsara Opportunity Fund GP, LLC ("Samsara Opportunity GP") Srinivas Akkaraju ("Dr. Akkaraju") The Reporting Persons expressly disclaim status as a "group" for purposes of this Schedule 13G. c/o Samsara BioCapital, LLC 628 Middlefield Road Palo Alto, CA 94301 Samsara LP Delaware Samsara GP Delaware Samsara Opportunity Fund Delaware Samsara Opportunity GP Delaware Dr. Akkaraju United States Y Row 9 of each Reporting Person's cover page to this Schedule 13G sets forth the aggregate number of shares of common stock of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. The Reporting Persons' ownership of the Issuer's securities consists of (i) 1,484,953 shares of common stock directly held by Samsara LP and (ii) 625,000 shares of common stock directly held by Samsara Opportunity Fund. Samsara GP is the sole general partner of Samsara LP and Dr. Akkaraju is the managing member of Samsara GP. Each of Samsara GP and Dr. Akkaraju possesses power to direct the voting and disposition of the securities held by Samsara LP. Samsara Opportunity GP is the sole general partner of Samsara Opportunity Fund and Dr. Akkaraju is the managing member of Samsara Opportunity GP. Each of Samsara Opportunity GP and Dr. Akkaraju possesses power to direct the voting and disposition of the securities held by Samsara Opportunity Fund. Row 11 of each Reporting Person's cover page to this Schedule 13G sets forth the percentages of shares of common stock of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. The percentage set forth in each row 11 is based upon 33,317,414 shares outstanding as of February 9, 2026, as reported in the Issuer's final prospectus dated February 5, 2026 filed with the Securities and Exchange Commission (the "SEC") on February 6, 2025. Row 5 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. Row 6 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. Row 7 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. Row 8 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person and is incorporated by reference. Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 Joint Filing Agreement Samsara BioCapital, L.P. /s/ Srinivas Akkaraju 02/17/2026 Samsara BioCapital GP, LLC /s/ Srinivas Akkaraju 02/17/2026 Samsara Opportunity Fund, L.P. /s/ Srinivas Akkaraju 02/17/2026 Samsara Opportunity Fund GP, LLC /s/ Srinivas Akkaraju 02/17/2026 Srinivas Akkaraju /s/ Srinivas Akkaraju 02/17/2026