<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2021-04-28</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001699382</issuerCik>
        <issuerName>PMV Pharmaceuticals, Inc.</issuerName>
        <issuerTradingSymbol>PMVP</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001825034</rptOwnerCik>
            <rptOwnerName>Euclidean Capital LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>160 FIFTH AVE, 9TH FL</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001825026</rptOwnerCik>
            <rptOwnerName>Greenland A LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EUCLIDEAN CAPITAL LLC</rptOwnerStreet1>
            <rptOwnerStreet2>160 FIFTH AVE, 9TH FL</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001825227</rptOwnerCik>
            <rptOwnerName>Greenland FP LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EUCLIDEAN CAPITAL LLC</rptOwnerStreet1>
            <rptOwnerStreet2>160 FIFTH AVE, 9TH FL</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001825238</rptOwnerCik>
            <rptOwnerName>Greenland NFP B Ltd.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EUCLIDEAN CAPITAL LLC</rptOwnerStreet1>
            <rptOwnerStreet2>160 FIFTH AVE, 9TH FL</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001825241</rptOwnerCik>
            <rptOwnerName>Greenland NFP LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EUCLIDEAN CAPITAL LLC</rptOwnerStreet1>
            <rptOwnerStreet2>160 FIFTH AVE, 9TH FL</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001861029</rptOwnerCik>
            <rptOwnerName>Symmetry Group Ltd.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EUCLIDEAN CAPITAL LLC</rptOwnerStreet1>
            <rptOwnerStreet2>160 FIFTH AVE, 9TH FL</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001825290</rptOwnerCik>
            <rptOwnerName>Simons Marilyn</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EUCLIDEAN CAPITAL LLC</rptOwnerStreet1>
            <rptOwnerStreet2>160 FIFTH AVE, 9TH FL</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001825293</rptOwnerCik>
            <rptOwnerName>Chhabra Ashvin</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EUCLIDEAN CAPITAL LLC</rptOwnerStreet1>
            <rptOwnerStreet2>160 FIFTH AVE, 9TH FL</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000941976</rptOwnerCik>
            <rptOwnerName>SIMONS JAMES H</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O EUCLIDEAN CAPITAL LLC</rptOwnerStreet1>
            <rptOwnerStreet2>160 FIFTH AVE, 9TH FL</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10010</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>693769</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2601637</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>751409</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>132601</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F4"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>494407</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F5"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The shares are held of record by Greenland A LLC, which is managed by Euclidean Capital LLC (&quot;Euclidean&quot;). Marilyn Simons and James Simons are owners and managers of Euclidean, and Ashvin Chhabra is President, CIO and Manager of Euclidean.</footnote>
        <footnote id="F2">The shares are held of record by Greenland NFP B Ltd., which is managed by Euclidean.</footnote>
        <footnote id="F3">The shares are held of record by Greenland FP LLC, which is managed by Euclidean.</footnote>
        <footnote id="F4">The shares are held of record by Greenland NFP LLC, which is managed by Euclidean.</footnote>
        <footnote id="F5">The shares are held of record by Symmetry Group Ltd (&quot;Symmetry&quot;). Mrs. Simons and Mr. Simons are on the board of directors of Symmetry's parent.</footnote>
        <footnote id="F6">Each of the Reporting Persons disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of the securities reported on this Form 3, except to the extent of any pecuniary interest therein.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Joseph Cosmai - Euclidean Capital LLC, By: Joseph Cosmai, Manager</signatureName>
        <signatureDate>2021-05-07</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Joseph Cosmai - Greenland A LLC, By: Joseph Cosmai, Manager of Euclidean Capital LLC, its Manager</signatureName>
        <signatureDate>2021-05-07</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Joseph Cosmai - Greenland FP LLC, By: Joseph Cosmai, Manager of Euclidean Capital LLC, its Manager</signatureName>
        <signatureDate>2021-05-07</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Joseph Cosmai - Greenland NFP B Ltd., By: Joseph Cosmai, Manager of Euclidean Capital LLC, its Manager</signatureName>
        <signatureDate>2021-05-07</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Joseph Cosmai - Greenland NFP LLC, By: Joseph Cosmai, Manager of Euclidean Capital LLC, its Manager</signatureName>
        <signatureDate>2021-05-07</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Jane Malone - Symmetry Group Ltd., By: Jane Malone, Officer of H.T.M. Services Ltd., its Director</signatureName>
        <signatureDate>2021-05-07</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Iona Gordon - Symmetry Group Ltd., By: Iona Gordon, Officer of H.T.M. Services Ltd., its Director</signatureName>
        <signatureDate>2021-05-07</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Marilyn Simons</signatureName>
        <signatureDate>2021-05-07</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Ashvin Chhabra</signatureName>
        <signatureDate>2021-05-07</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ James Simons</signatureName>
        <signatureDate>2021-05-07</signatureDate>
    </ownerSignature>
</ownershipDocument>
