144 0002024196 XXXXXXXX LIVE 0001699031 GRAIL, Inc. 001-42045 1525 O'Brien Dr. Meno Park CA 94025 415-528-0644 Aaron Freidin Officer Common Stock ETRADE FINANCIAL CORPORATION

3 EDISON DRIVE ALPHARETTA GA 30005

42138 1551099.78 35296858 05/01/2025 NASDAQ Common Stock 06/28/2024 Shares acquired upon vesting of restricted stock units awarded under Issuer's equity incentive plans Issuer N 79966 06/28/2024 Services rendered N Aaron Friedin

1525 O'Brien Drive Menlo Park CA 94025

Common Stock 03/05/2025 521 21626.71 Aaron Friedin

1525 O'Brien Drive Menlo Park CA 94025

Common Stock 03/11/2025 1816 56659.2 Represents an estimate of shares expected to be sold to cover tax obligations upon vesting of restricted stock units on April 30th, 2025, based on an estimated price per share of $36.81, which was the closing price of a share of the Company's common stock on April 29, 2025. 04/29/2025 /s/ Donald Lang, as Attorney-in-Fact for Aaron Freidin