144 0001822088 XXXXXXXX LIVE 0001699031 GRAIL, Inc. 001-42045 1525 O'Brien Dr. Menlo Park CA 94025 415-528-0644 Joshua J. Ofman Officer Common Stock ETRADE FINANCIAL CORPORATION

3 EDISON DRIVE ALPHARETTA GA 30005

47083 1733136.27 35296858 05/01/2025 NASDAQ Common Stock 06/28/2024 Shares acquired upon vesting of restricted stock units awarded under Issuer's equity incentive plans Issuer N 92269 06/28/2024 Services rendered N Joshua J. Ofman

1525 O'Brien Drive Menlo Park CA 94025

Common Stock 03/05/2025 525 21792.75 Joshua J. Ofman

1525 O'Brien Drive Menlo Park CA 94025

Common Stock 03/11/2025 2109 65800.8 Represents an estimate of shares expected to be sold to cover tax obligations upon vesting of restricted stock units on April 30th, 2025, based on an estimated price per share of $36.81, which was the closing price of a share of the Company's common stock on April 29, 2025. 04/29/2025 /s/ Donald Lang, as Attorney-in-Fact for Joshua Ofman