144 0001822088 XXXXXXXX LIVE 0001699031 GRAIL, Inc. 001-42045 1525 O'Brien Dr. Menlo Park CA 94025 415-528-0644 Joshua J. Ofman Officer Common Stock ETRADE FINANCIAL CORPORATION

3 EDISON DRIVE ALPHARETTA GA 30005

2897 105248.01 33895246 03/05/2025 NASDAQ Common Stock 06/28/2024 Shares acquired upon vesting of restricted stock units awarded under Issuer's equity incentive plans Issuer N 6830 06/28/2024 Services rendered Y Represents an estimate of shares expected to be sold to cover tax obligations upon vesting of restricted stock units on March 4th and 6th, 2025, based on an estimated price per share of $36.33, which was the closing price of a share of the Company's common stock on March 3, 2025. 03/03/2025 /s/ Joshua Ofman