144 0001822088 XXXXXXXX LIVE 0001699031 GRAIL, Inc. 001-42045 1525 OBrien Drive Menlo Park CA 94025 415-528-0644 Joshua Ofman Officer Director Common Stock ETRADE FINANCIAL CORPORATION

3 EDISON DRIVE ALPHARETTA GA 30005

66522 3441848.28 41134219 04/06/2026 NASDAQ Common Stock 04/03/2026 Shares acquired upon vesting of restricted stock units awarded under Issuer's equity incentive plans Issuer N 106970 04/03/2026 Services rendered N Joshua J. Ofman

1525 O'Brien Drive Menlo Park CA 94025

Common Stock 03/02/2026 17002 852847.77 Joshua J. Ofman

1525 O'Brien Drive Menlo Park CA 94025

Common Stock 03/05/2026 690 36576.9 Joshua J. Ofman

1525 O'Brien Drive Menlo Park CA 94025

Common Stock 03/09/2026 2937 140650.22 Represents an estimate of shares expected to be sold to cover tax obligations upon vesting of restricted stock units on April 3rd, 2026, based on an estimated price per share of $51.74, which was the closing price of a share of the Company's common stock on April 6, 2026. 04/06/2026 /s/Donald Lang, as Attorneyin-Fact for Joshua Ofman