144 0001222644 XXXXXXXX LIVE 0001699031 GRAIL, INC. 001-42045 1525O'Brien Dr Menlo Park CA 94025 415-528-0644 Robert Ragusa Officer Director Common Stock ETRADE FINANCIAL CORPORATION

3 EDISON DRIVE ALPHARETTA GA 30005

133230 6893320.2 41134219 04/06/2026 NASDAQ Common Stock 04/03/2026 Shares acquired upon vesting of restricted stock units awarded under Issuer's equity incentive plans Issuer N 214240 04/03/2026 Services rendered N RAGUSA ROBERT P

1525 O'Brien Drive Menlo Park CA 94025

Common Stock 03/02/2026 37504 1881417.06 RAGUSA ROBERT P

1525 O'Brien Drive Menlo Park CA 94025

Common Stock 03/05/2026 980 51949.8 RAGUSA ROBERT P

1525 O'Brien Drive Menlo Park CA 94025

Common Stock 03/09/2026 7461 357296.13 Represents an estimate of shares expected to be sold to cover tax obligations upon vesting of restricted stock units on April 3rd, 2026, based on an estimated price per share of $51.74, which was the closing price of a share of the Company's common stock on April 6, 2026. 04/06/2026 /s/Donald Lang, as Attorney-in-Fact for Robert Ragusa