144 0001222644 XXXXXXXX LIVE 0001699031 GRAIL, Inc. 001-42045 1525 O'Brien Drive Menlo Park CA 94025 415-528-0644 Robert Ragusa Officer Director Common Stock ETRADE FINANCIAL CORPORATION

3 EDISON DRIVE ALPHARETTA GA 30005

9285 480963 40990388 03/05/2026 NASDAQ Common Stock 03/04/2026 Shares acquired upon vesting of restricted stock units awarded under Issuer's equity incentive plans Issuer N 1891 03/04/2026 Services rendered Common Stock 03/06/2026 Shares acquired upon vesting of restricted stock units awarded under Issuer's equity incentive plans Issuer N 14006 03/06/2026 Services rendered N RAGUSA ROBERT P

1525 O'Brien Drive Menlo Park CA 94025

Common Stock 03/02/2026 37504 1302767 Represents an estimate of shares expected to be sold to cover tax obligations upon vesting of restricted stock units on March 4th and March 6th, 2026, based on an estimated price per share of $51.80, which was the closing price of a share of the Company's common stock on March 5, 2026. 03/05/2026 /s/ Donald Lang, as Attorney-in-Fact for Robert Ragusa