144 0001222644 XXXXXXXX LIVE 0001699031 GRAIL, Inc. 001-42045 1525O'Brien Drive Menlo Park CA 94025 415-528-0644 Robert Ragusa Officer Director Common Stock ETRADE FINANCIAL CORPORATION

3 EDISON DRIVE ALPHARETTA GA 30005

40641 2163320.43 40341120 03/02/2026 NASDAQ Common Stock 02/28/2026 Shares acquired upon vesting of restricted stock units awarded under Issuer's equity incentive plans Issuer N 74873 02/28/2026 Services rendered N Robert Ragusa

1525 O'Brien Drive Menlo Park CA 94025

Common Stock 12/03/2025 40000 3809534.92 Represents an estimate of shares expected to be sold to cover tax obligations upon vesting of restricted stock units on February 28th, 2026, based on an estimated price per share of $53.23, which was the closing price of a share of the Company's common stock on February 27, 2026. 03/02/2026 /s/ Donald Lang, as Attorney-in-Fact for Robert Ragusa