SCHEDULE 13G/A 0001110803 XXXXXXXX LIVE 1 Common Stock, $0.001 par value 12/31/2025 0001699031 GRAIL, INC. 384747101 1525 O'Brien Drive Menlo Park CA 94025 Rule 13d-1(d) Illumina, Inc. DE 1302126.00 0.00 1302126.00 0.00 1302126.00 N 3.2 CO Note 1: The figure in boxes 5, 7 and 9 represents shares of Common Stock of GRAIL, Inc. (the "Company") directly or indirectly beneficially owned by Illumina, Inc. ("Illumina") as of February 17, 2026, the date of this filing. As of December 31, 2025, Illumina, Inc. ("Illumina") directly or indirectly beneficially owned 2,502,126 shares of the Company's Common Stock. Note 2: For Box 11, the denominator for this calculation is based on 40,800,541 shares of Common Stock outstanding as of November 14, 2025, as reported in GRAIL's prospectus supplement dated November 14, 2025 to its Registration Statement on Form S-3 filed with the U.S. Securities and Exchange Commission on November 13, 2025. GRAIL, INC. 1525 O'Brien Drive, Menlo Park, California, 94025 Illumina, Inc. 5200 Illumina Way, San Diego, CA 92122 Delaware Y 1,302,126 3.2% 1,302,126 0 1,302,126 0 N Y Y Y Y Y N Illumina, Inc. /s/ Ankur Dhingra 02/17/2026