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We consent to the incorporation by reference in the Registration Statement of Exicure, Inc on Forms S-8 (Nos. 333-222999, 333-237043, 333-254189, and 333-263876) and Forms S-3 (Nos. 333-221791, 333-227475, and 333-266093) of our report dated March 18, 2025, which includes an explanatory paragraph as to the Company’s ability to continue as a going concern, with respect to our audits of the consolidated financial statements of Exicure, Inc. as of December 31, 2024 and 2023, and for the years ended December 31, 2024 and 2023, which report is included in this Annual Report on Form 10-K of Exicure, Inc. for the year ended December 31, 2024.