SCHEDULE 13G/A 0001104659-20-113823 0001697748 XXXXXXXX LIVE 6 Common Stock 12/31/2025 0001299130 Pacific Biosciences of California, Inc. 69404D108 1305 O'Brien Drive Menlo Park CA 94025 Rule 13d-1(b) ARK Investment Management LLC DE 34971286.00 620864.00 37264228.00 0.00 37264228.00 N 12.34 IA Catherine D. Wood X1 0.00 35592150.00 0.00 37264228.00 37264228.00 N 12.34 HC IN Pacific Biosciences of California, Inc. 1305 O'Brien Drive, Menlo Park, CA, 94025 (i) ARK Investment Management LLC ("ARK") (ii) Catherine D. Wood ARK and Catherine D. Wood: 200 Central Avenue, St. Petersburg, FL 33701 (i) ARK: Delaware (ii) Catherine D. Wood: United States N IA HC ARK and Catherine D. Wood: 37,264,228 ARK and Catherine D. Wood: 12.34 (i) ARK: 34,971,286 (ii) Catherine D. Wood: 0 (i) ARK: 620,864 (ii) Catherine D. Wood: 35,592,150 (i) ARK: 37,264,228 (ii) Catherine D. Wood: 0 (i) ARK: 0 (ii) Catherine D. Wood: 37,264,228 Y N No client of ARK Investment Management LLC currently has an interest in the securities reported herein in excess of 5 percent except ARK Innovation ETF, a series of a Delaware statutory trust. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. ARK Investment Management LLC /s/ Kellen Carter 02/03/2026 Catherine D. Wood /s/ Catherine D. Wood 02/03/2026