SCHEDULE 13G/A 0001144204-19-007776 0001697748 XXXXXXXX LIVE 8 Common Stock 06/30/2025 0001768224 Arcturus Therapeutics Holdings Inc. 03969T109 10628 Science Center Drive Suite 250 San Diego CA 92121 Rule 13d-1(b) ARK Investment Management LLC DE 1715040.00 0.00 1715040.00 0.00 1715040.00 N 6.32 IA Catherine D. Wood X1 0.00 1715040.00 0.00 1715040.00 1715040.00 N 6.32 HC IN Arcturus Therapeutics Holdings Inc. 10628 Science Center Drive, Suite 250, San Diego, CA 92121 (i) ARK Investment Management LLC ("ARK") (ii) Catherine D. Wood ARK and Catherine D. Wood: 200 Central Avenue, St. Petersburg, FL 33701 (i) ARK: Delaware (ii) Catherine D. Wood: United States N IA HC ARK and Catherine D. Wood: 1,715,040 ARK and Catherine D. Wood: 6.32% (i) ARK: 1,715,040 (ii) Catherine D. Wood: 0 (i) ARK: 0 (ii) Catherine D. Wood: 1,715,040 (i) ARK: 1,715,040 (ii) Catherine D. Wood: 0 (i) ARK: 0 (ii) Catherine D. Wood: 1,715,040 Y N No client of ARK Investment Management LLC currently has an interest in the securities reported herein in excess of 5 percent except ARK Genomic Revolution ETF, a series of a Delaware statutory trust. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. ARK Investment Management LLC /s/ Kellen Carter 07/30/2025 Catherine D. Wood /s/ Catherine D. Wood 07/30/2025