The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
Aerojet Rocketdyne Holdings InCommon Stock0078001052,24456,108SH SOLE 56,10800
AeroVironment IncCommon Stock00807310862,536750,191SH SOLE 750,19100
Align Technology IncCommon Stock0162551012,56812,398SH SOLE 12,39800
ATI IncCommon Stock01741R1022639,877SH SOLE 9,87700
Alphabet IncCommon Stock02079K10725,157261,648SH SOLE 261,64800
Altair Engineering IncCommon Stock0213691036,126138,538SH SOLE 138,53800
Amazon.com IncCommon Stock0231351067,51266,482SH SOLE 66,48200
AMETEK IncCommon Stock0311001003,21028,304SH SOLE 28,30400
ANSYS IncCommon Stock03662Q10519,45487,748SH SOLE 87,74800
Arcturus Therapeutics HoldingsCommon Stock03969T10932,3332,181,703SH SOLE 2,181,70300
Autodesk IncCommon Stock0527691067,47340,007SH SOLE 40,00700
Renishaw PLCCommon StockG750061174,943126,313SH SOLE 126,31300
CareDx IncCommon Stock14167L10398,4975,787,120SH SOLE 5,787,12000
Carpenter Technology CorpCommon Stock1442851032538,124SH SOLE 8,12400
Cerus CorpCommon Stock15708510160,67416,853,875SH SOLE 15,646,843467,095739,937
Codexis IncCommon Stock19200510625,8974,273,485SH SOLE 4,273,48500
Deere & CoCommon Stock24419910558,988176,668SH SOLE 176,66800
DuPont de Nemours IncCommon Stock26614N1022104,174SH SOLE 4,17400
Eastman Chemical CoCommon Stock2774321001772,498SH SOLE 2,49800
Editas Medicine IncCommon Stock28106W1031,778145,292SH SOLE 44,025101,2670
FARO Technologies IncCommon Stock3116421026,437234,583SH SOLE 234,58300
Fate Therapeutics IncCommon Stock31189P102261,20711,655,833SH SOLE 11,440,7400215,093
Grayscale Bitcoin Trust BTCOpen-End Fund38963710974,0646,491,122SH SOLE 5,865,715616,8628,545
HP IncCommon Stock40434L1054,652186,681SH SOLE 186,68100
Hexcel CorpCommon Stock4282911082174,187SH SOLE 4,18700
Incyte CorpCommon Stock45337C10268,6521,030,189SH SOLE 1,030,18900
Intellia Therapeutics IncCommon Stock45826J105540,4099,657,052SH SOLE 8,723,670628,100305,282
Intercontinental Exchange IncCommon Stock45866F1049,00199,628SH SOLE 99,62800
Intuit IncCommon Stock46120210311,92530,788SH SOLE 30,78800
Intuitive Surgical IncCommon Stock46120E60210,17954,304SH SOLE 54,30400
OC Oerlikon Corp AGCommon StockH591871062,113327,398SH SOLE 327,39800
Invitae CorpCommon Stock46185L10374,95230,468,381SH SOLE 26,232,6963,069,2371,166,448
Ionis Pharmaceuticals IncCommon Stock462222100164,2313,713,107SH SOLE 3,713,10700
Iovance Biotherapeutics IncCommon Stock46226010022,1992,317,217SH SOLE 2,317,21700
Iridium Communications IncCommon Stock46269C10278,4811,768,780SH SOLE 1,768,78000
JD.com IncADR47215P1068,349165,976SH SOLE 165,97600
SGL Carbon SECommon StockD6949M10821837,860SH SOLE 37,86000
Kaiser Aluminum CorpCommon Stock4830077041,81029,508SH SOLE 29,50800
Komatsu LtdADR50045840132,2071,769,607SH SOLE 1,769,60700
Kratos Defense & Security SoluCommon Stock50077B20783,2078,189,644SH SOLE 8,189,64400
Henkel AG & Co KGaAPreferenceD3207M1102193,694SH SOLE 3,69400
Lincoln Electric Holdings IncCommon Stock5339001062,30718,349SH SOLE 18,34900
Siemens AGCommon StockD696712182,21222,710SH SOLE 22,71000
Materialise NVADR57667T10062,7825,861,998SH SOLE 5,567,729138,873155,396
MercadoLibre IncCommon Stock58733R10273,90489,280SH SOLE 89,28000
Microsoft CorpCommon Stock5949181046,39327,449SH SOLE 27,44900
Bezeq The Israeli TelecommunicCommon StockM2012Q1002,4441,487,558SH SOLE 1,487,55800
Moog IncCommon Stock6153942021,98028,139SH SOLE 28,13900
Danel Adir Yeoshua LtdCommon StockM270131071,99918,957SH SOLE 18,95700
Hilan LtdCommon StockM5299H1232,26142,080SH SOLE 42,08000
Nano Dimension LtdADR63008G2034,1041,717,194SH SOLE 1,717,19400
Elbit Systems LtdCommon StockM3760D10130,588160,845SH SOLE 160,84500
Partner Communications Co LtdCommon StockM784651072,235308,441SH SOLE 308,44100
Nice LtdADR6536561082,17311,542SH SOLE 11,54200
Matrix IT LtdCommon StockM6859E1532,22397,670SH SOLE 97,67000
Toray Industries IncCommon StockJ8949411621343,253SH SOLE 43,25300
PTC IncCommon Stock69370C1007,27669,565SH SOLE 69,56500
Pacific Biosciences of CaliforCommon Stock69404D108166,56028,692,494SH SOLE 26,930,3471,311,970450,177
One Software Technologies LtdCommon StockM752601132,320152,742SH SOLE 152,74200
Personalis IncCommon Stock71535D10616,1765,446,512SH SOLE 5,446,51200
Proto Labs IncCommon Stock74371310920,513563,078SH SOLE 563,07800
Roku IncCommon Stock77543R102672,16811,917,866SH SOLE 10,913,099747,205257,562
Shopify IncCommon Stock82509L107391,50614,532,528SH SOLE 13,574,018727,595230,915
Block IncCommon Stock852234103505,4579,191,790SH SOLE 8,545,023470,877175,890
Teladoc Health IncCommon Stock87918A105528,75820,858,302SH SOLE 19,320,2571,091,467446,578
Teradyne IncCommon Stock88077010241,507552,318SH SOLE 552,31800
Tesla IncCommon Stock88160R1011,082,4634,080,917SH SOLE 3,831,303249,6140
Teva Pharmaceutical IndustriesADR8816242092,707335,468SH SOLE 335,46800
3D Systems CorpCommon Stock88554D20530,9013,872,253SH SOLE 3,872,25300
3M CoCommon Stock88579Y1011961,777SH SOLE 1,77700
Trimble IncCommon Stock896239100110,2682,031,843SH SOLE 2,031,84300
Twilio IncCommon Stock90138F102471,9936,826,631SH SOLE 6,301,973388,202136,456
Twist Bioscience CorpCommon Stock90184D100235,2946,676,908SH SOLE 6,444,517134,51197,880
2U IncCommon Stock90214J10158,8299,412,719SH SOLE 8,300,412701,885410,422
United Parcel Service IncCommon Stock9113121061,98912,310SH SOLE 12,31000
Veracyte IncCommon Stock92337F107150,7519,081,363SH SOLE 8,533,958547,4050
Xerox Holdings CorpCommon Stock98421M10621016,080SH SOLE 16,08000
Zillow Group IncCommon Stock98954M20022,604790,076SH SOLE 790,07600
Koninklijke DSM NVCommon StockN5017D1221811,577SH SOLE 1,57700
Arkema SACommon StockF0392W1251952,656SH SOLE 2,65600
Sandvik ABCommon StockW7485716518213,283SH SOLE 13,28300
Cellcom Israel LtdCommon StockM2196U1092,310452,436SH SOLE 452,43600
Evonik Industries AGCommon StockD2R90Y11719511,684SH SOLE 11,68400
Fattal Holdings 1998 LtdCommon StockM4148G1052,07621,237SH SOLE 21,23700
SLM Solutions Group AGCommon StockD6T6901099,881514,944SH SOLE 514,94400
Adyen NVCommon StockN3501V10430,18823,687SH SOLE 23,68700
Sapiens International Corp NVCommon StockG7T16G1031,84696,234SH SOLE 96,23400
CRISPR Therapeutics AGCommon StockH17182108538,2968,237,122SH SOLE 7,523,953508,781204,388
Spotify Technology SACommon StockL8681T10269,065800,291SH SOLE 752,81532,72414,752
Allot LtdCommon StockM0854Q1051,689430,921SH SOLE 430,92100
AudioCodes LtdCommon StockM153421042,275104,308SH SOLE 104,30800
Camtek Ltd/IsraelCommon StockM207911051,89981,958SH SOLE 81,95800
Ceragon Networks LtdCommon StockM220131021,688922,505SH SOLE 922,50500
Check Point Software TechnologCommon StockM224651042,13819,090SH SOLE 19,09000
Compugen LtdCommon StockM257221057601,157,484SH SOLE 1,157,48400
CyberArk Software LtdCommon StockM2682V1082,60817,393SH SOLE 17,39300
Fiverr International LtdCommon StockM4R82T1061,92162,808SH SOLE 62,80800
Ituran Location and Control LtCommon StockM6158M1042,30298,646SH SOLE 98,64600
Nova LtdCommon StockM7516K1032,05524,095SH SOLE 24,09500
Radware LtdCommon StockM818731072,352107,930SH SOLE 107,93000
Stratasys LtdCommon StockM8554810122,6681,573,088SH SOLE 1,307,3070265,781
Taro Pharmaceutical IndustriesCommon StockM8737E1081,83761,287SH SOLE 61,28700
Tower Semiconductor LtdCommon StockM879152742,32953,012SH SOLE 53,01200
UroGen Pharma LtdCommon StockM960881052,344281,701SH SOLE 281,70100
Wix.com LtdCommon StockM980681052,84736,392SH SOLE 36,39200
DocuSign IncCommon Stock25616310603SH SOLE 300
Discovery LtdCommon StockS2192Y10930,6625,281,320SH SOLE 5,281,32000
Inmode LtdCommon StockM5425M1032,40582,607SH SOLE 82,60700
Perion Network LtdCommon StockM786731142,377123,205SH SOLE 123,20500
Silvergate Capital CorpCommon Stock82837P40831,697420,660SH SOLE 420,66000
Z Holdings CorpCommon StockJ9894K10511,8734,519,214SH SOLE 4,519,21400
Sea LtdADR81141R10015,049268,486SH SOLE 245,78122,7050
Z Holdings CorpADR98877X101519,732SH SOLE 9,73200
Synopsys IncCommon Stock87160710714,49047,428SH SOLE 47,42800
RADA Electronic Industries LtdCommon StockM818631242,432252,562SH SOLE 252,56200
PagerDuty IncCommon Stock69553P100249,65010,821,427SH SOLE 9,740,550765,343315,534
Caterpillar IncCommon Stock14912310115,78396,189SH SOLE 96,18900
Arconic CorpCommon Stock03966V1071,33478,315SH SOLE 78,31500
Adaptive Biotechnologies CorpCommon Stock00650F10966,4779,336,619SH SOLE 9,336,61900
10X Genomics IncCommon Stock88025U109130,3484,576,814SH SOLE 4,192,535288,66395,616
Bitcoin Fund/TheClosed-End Fund09175G1042,461128,634SH SOLE 00128,634
Schrodinger Inc/United StatesCommon Stock80810D10394,0423,764,707SH SOLE 3,764,70700
TCS Group Holding PLCGDR87238U2030608,351SH SOLE 608,35100
Adyen NVADR00783V10413,9911,117,498SH SOLE 1,117,49800
voestalpine AGCommon StockA9101Y10320011,673SH SOLE 11,67300
Accolade IncCommon Stock00437E10267,5885,918,365SH SOLE 5,918,36500
Berkeley Lights IncCommon Stock08431010115,6415,468,825SH SOLE 5,468,82500
Vertex Pharmaceuticals IncCommon Stock92532F10045,587157,445SH SOLE 157,44500
BYD Co LtdADR05606L10014,243289,795SH SOLE 289,79500
Gilat Satellite Networks LtdCommon StockM514741181,957367,177SH SOLE 367,17700
Silicom LtdCommon StockM841161082,34466,329SH SOLE 66,32900
Organovo Holdings IncCommon Stock68620A203563274,867SH SOLE 271,8603,0070
Surface Oncology IncCommon Stock86877M2096,2776,035,691SH SOLE 6,035,69100
Niu TechnologiesADR65481N1009,4362,301,438SH SOLE 2,301,43800
Exact Sciences CorpCommon Stock30063P105570,58017,561,702SH SOLE 16,293,346933,914334,442
Unity Software IncCommon Stock91332U101358,84411,263,159SH SOLE 10,254,274752,121256,764
Beam Therapeutics IncCommon Stock07373V105404,5088,490,936SH SOLE 8,490,93600
Regeneron Pharmaceuticals IncCommon Stock75886F10725,44836,941SH SOLE 36,94100
Repare Therapeutics IncCommon Stock76027310231,9262,632,028SH SOLE 2,632,02800
Cloudflare IncCommon Stock18915M10717,163310,308SH SOLE 310,30800
Palantir Technologies IncCommon Stock69608A1081,792220,404SH SOLE 30,115190,2890
Zoom Video Communications IncCommon Stock98980L101801,49410,891,340SH SOLE 9,990,792652,241248,307
Honeywell International IncCommon Stock4385161063,93023,536SH SOLE 23,53600
Kaspi.KZ JSCGDR48581R20511,530198,793SH SOLE 198,79300
908 Devices IncCommon Stock65443P10262,1023,775,194SH SOLE 3,775,19400
Magna International IncCommon Stock55922240116,653351,174SH SOLE 351,17400
Veeva Systems IncCommon Stock92247510837,790229,200SH SOLE 229,20000
Grayscale Ethereum TrustOpen-End Fund3896381075,577611,510SH SOLE 2,880608,6300
PyroGenesis Canada IncCommon Stock74734T104150136,698SH SOLE 136,69800
Magic Software Enterprises LtdCommon Stock5591661031,931124,131SH SOLE 124,13100
Malam - Team LtdCommon StockM874371052,240102,690SH SOLE 102,69000
Desktop Metal IncCommon Stock25058X1056,1222,363,523SH SOLE 2,363,52300
JFrog LtdCommon StockM6191J1002,384107,815SH SOLE 107,81500
Eastman Kodak CoCommon Stock27746140621045,731SH SOLE 45,73100
Lockheed Martin CorpCommon Stock53983010913,20434,182SH SOLE 34,18200
Nano-X Imaging LtdCommon StockM707001052,070180,478SH SOLE 180,47800
Teledyne Technologies IncCommon Stock87936010514,56343,154SH SOLE 43,15400
Twitter IncCommon Stock90184L102253SH SOLE 5300
Butterfly Network IncCommon Stock12415510250,95210,840,899SH SOLE 10,840,89900
Signify Health IncCommon Stock82671G10061,0932,095,811SH SOLE 2,060,119035,692
ARK Innovation ETFETP00214Q1043589,493SH SOLE 9,49300
Bill.com Holdings IncCommon Stock09004310022,241168,018SH SOLE 168,01800
Vuzix CorpCommon Stock92921W30038,0366,569,273SH SOLE 6,569,27300
Airbus SECommon StockN0280G1002,89133,223SH SOLE 33,22300
Thales SACommon StockF9156M1085,04545,603SH SOLE 45,60300
Komatsu LtdCommon StockJ3575912510,403576,588SH SOLE 576,58800
Garmin LtdCommon StockH2906T1094,69758,486SH SOLE 58,48600
HEICO CorpCommon Stock4228061093,16121,957SH SOLE 21,95700
L3Harris Technologies IncCommon Stock50243110915,78475,946SH SOLE 75,94600
The 3D Printing ETFETP00214Q50014,874753,105SH SOLE 753,10500
ROBLOX CorpCommon Stock771049103303,7338,474,696SH SOLE 7,808,370496,067170,259
Spirit AeroSystems Holdings InCommon Stock8485741093,679167,853SH SOLE 167,85300
UiPath IncCommon Stock90364P105581,12046,084,074SH SOLE 43,405,0141,928,937750,123
Coinbase Global IncCommon Stock19260Q107497,6787,717,135SH SOLE 7,106,963474,835135,337
TuSimple Holdings IncCommon Stock90089L108122,35516,099,348SH SOLE 14,688,7901,077,582332,976
Recursion Pharmaceuticals IncCommon Stock75629V10435,7483,359,811SH SOLE 3,359,81100
Zymergen IncCommon Stock98985X10020,8007,482,047SH SOLE 7,482,04700
Blade Air Mobility IncCommon Stock09266710429,5787,339,527SH SOLE 7,339,52700
JD Logistics IncCommon StockG5074S1017,2054,098,426SH SOLE 4,098,42600
Hexagon ABCommon StockW4R4311122,842301,655SH SOLE 301,65500
StoneCo LtdCommon StockG8515810624,7232,594,177SH SOLE 2,594,17700
Quantum-Si IncCommon Stock74765K10536,40413,237,790SH SOLE 13,237,79000
Verve Therapeutics IncCommon Stock92539P101116,5793,393,859SH SOLE 3,340,46929,63023,760
Markforged Holding CorpCommon Stock57064N10232,94716,639,680SH SOLE 16,639,68000
Dassault Systemes SECommon StockF2457145114,584416,882SH SOLE 416,88200
Exco Technologies LtdCommon Stock30150P1092,055365,949SH SOLE 365,94900
Xometry IncCommon Stock98423F1099,864173,697SH SOLE 173,69700
BICO Group ABCommon StockW2R45B1043,4621,297,756SH SOLE 1,297,75600
Farfetch LtdCommon Stock30744W1075,143690,296SH SOLE 690,29600
Robinhood Markets IncCommon Stock770700102332,39632,910,470SH SOLE 30,272,0472,057,223581,200
Playtika Holding CorpCommon Stock72815L1071,748186,134SH SOLE 186,13400
Cognyte Software LtdCommon StockM251331052,187541,367SH SOLE 541,36700
Monday.com LtdCommon StockM7S64H10629,667261,749SH SOLE 261,74900
SimilarWeb LtdCommon StockM841371041,351230,500SH SOLE 230,50000
WalkMe LtdCommon StockM976281072,124249,939SH SOLE 249,93900
Joby Aviation IncCommon StockG651631005,5201,274,784SH SOLE 1,274,78400
General Electric CoCommon Stock3696043012,22435,923SH SOLE 35,92300
Pfizer IncCommon Stock71708110323,316532,812SH SOLE 532,81200
Genius Sports LtdCommon StockG3934V10918,5965,066,909SH SOLE 5,066,90900
ARK Genomic Revolution ETFETP00214Q302521,581SH SOLE 1,58100
Ginkgo Bioworks Holdings IncCommon Stock37611X100395,675126,818,856SH SOLE 119,338,5065,428,4222,051,928
SomaLogic IncCommon Stock83444K10531,95111,017,672SH SOLE 11,017,67200
SomaLogic IncEquity WRT83444K113132300,000SHCallSOLE 300,00000
Archer Aviation IncCommon Stock03945R10224,8059,503,688SH SOLE 9,503,68800
Toast IncCommon Stock88878710825,9501,552,023SH SOLE 1,552,02300
Velo3D IncCommon Stock92259N10443,50611,042,242SH SOLE 11,042,24200
MYNARIC AGNAMENS AKTIEN O NADR62857X1012,653545,819SH SOLE 545,81900
Nextdoor Holdings IncCommon Stock65345M10817,8476,396,764SH SOLE 6,396,76400
Crowdstrike Holdings IncCommon Stock22788C10513,72683,285SH SOLE 83,28500
NVIDIA CorpCommon Stock67066G104167,8371,382,624SH SOLE 1,296,23364,72421,667
NU Holdings Ltd/Cayman IslandsCommon StockG6683N10320,4814,654,774SH SOLE 4,654,77400
Nurix Therapeutics IncCommon Stock67080M10316,7631,286,522SH SOLE 1,286,52200
XPeng IncCommon StockG982AW1005,174882,968SH SOLE 882,96800
Endeavor Group Holdings IncCommon Stock29260Y1099,228455,485SH SOLE 455,48500
Hyperfine IncCommon Stock44916K1068101,000,000SH SOLE 1,000,00000
Atlantic Coastal Acquisition CCommon Stock0484531045,838594,548SH SOLE 594,54800
Fathom Digital Manufacturing CCommon Stock31189Y1032,3811,173,073SH SOLE 1,173,07300
Global-e Online LtdCommon StockM5216V10626,646995,735SH SOLE 995,73500
Cellebrite DI LtdCommon StockM2197Q1071,663424,199SH SOLE 424,19900
ironSource LtdCommon StockM5R75Y1011,989578,176SH SOLE 578,17600
Riskified LtdCommon StockM8216R1092,265574,994SH SOLE 574,99400
Taboola.com LtdCommon StockM8744T1061,470812,413SH SOLE 812,41300
ATAI Life Sciences NVCommon StockN0731H10320,3206,138,914SH SOLE 6,138,91400
NIO IncADR62914V1065,717362,506SH SOLE 362,50600
Straumann Holding AGCommon StockH8300N1274,52448,466SH SOLE 48,46600
DraftKings IncCommon Stock26142V105374,07024,707,394SH SOLE 22,968,4571,255,360483,577
General Motors CoCommon Stock37045V1008,318259,195SH SOLE 259,19500
Cie Generale des EtablissementCommon StockF618248701,89283,484SH SOLE 83,48400
Moderna IncCommon Stock60770K10719,345163,592SH SOLE 163,59200
Senti Biosciences IncCommon Stock81726A1004,5302,087,696SH SOLE 2,087,69600
Guardant Health IncCommon Stock40131M10929,182542,113SH SOLE 542,11300
HUB Cyber Security Israel LtdCommon StockM0182S1042,1411,404,532SH SOLE 1,404,53200
Alleima ABCommon StockW7492510382,657SH SOLE 2,65700
Compass Pathways PlcADR20451W1014,169388,574SH SOLE 388,57400
Rocket Lab USA IncCommon Stock7731221063,520864,987SH SOLE 864,98700
Adobe IncCommon Stock00724F1016,23422,654SH SOLE 22,65400
ARK Genomic Revolution ETFETP00214Q302722,200SHCallSOLE 2,20000
ARK Innovation ETFETP00214Q1043178,400SHCallSOLE 8,40000
Coinbase Global IncCommon Stock19260Q1071612,500SHCallSOLE 2,50000
CRISPR Therapeutics AGCommon StockH17182108851,300SHCallSOLE 1,30000
DraftKings IncCommon Stock26142V1051509,900SHCallSOLE 9,90000
Exact Sciences CorpCommon Stock30063P10526800SHCallSOLE 80000
Intel CorpCommon Stock458140100361,400SHPutSOLE 1,40000
Pacific Biosciences of CaliforCommon Stock69404D108427,200SHCallSOLE 7,20000
Roku IncCommon Stock77543R102681,200SHCallSOLE 1,20000
Block IncCommon Stock8522341031482,700SHCallSOLE 2,70000
Teladoc Health IncCommon Stock87918A10515600SHCallSOLE 60000
Tesla IncCommon Stock88160R1013981,500SHCallSOLE 1,50000
Energy Select Sector SPDR FundETP81369Y5063965,500SHPutSOLE 5,50000
Zoom Video Communications IncCommon Stock98980L1016929,400SHCallSOLE 9,40000