The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
Adobe IncCommon Stock00724F10153,822107,619SH SOLE 107,61900
Aerojet Rocketdyne Holdings InCommon Stock0078001051,27124,044SH SOLE 24,04400
AeroVironment IncCommon Stock00807310835,344406,726SH SOLE 406,72600
Alibaba Group Holding LtdADR01609W102125,075537,424SH SOLE 537,42400
Align Technology IncCommon Stock0162551012,1734,066SH SOLE 4,06600
Allegheny Technologies IncCommon Stock01741R10225915,429SH SOLE 15,42900
Alphabet IncCommon Stock02079K10764,66436,911SH SOLE 36,91100
Altair Engineering IncCommon Stock0213691035,978102,744SH SOLE 102,74400
Amazon.com IncCommon Stock02313510673,29422,504SH SOLE 22,50400
AMETEK IncCommon Stock0311001001,52612,621SH SOLE 12,62100
ANSYS IncCommon Stock03662Q10528,10977,265SH SOLE 77,26500
Apple IncCommon Stock037833100121,398914,900SH SOLE 914,90000
AquaBounty Technologies IncCommon Stock03842K20075,6908,640,421SH SOLE 8,640,42100
Arcturus Therapeutics HoldingsCommon Stock03969T109171,7423,959,019SH SOLE 3,959,01900
Autodesk IncCommon Stock05276910622,56573,902SH SOLE 73,90200
Baidu IncADR056752108488,8702,260,776SH SOLE 2,153,07159,33548,370
Renishaw PLCCommon StockG750061175,78973,622SH SOLE 73,62200
CareDx IncCommon Stock14167L103294,3154,062,322SH SOLE 4,062,32200
Carpenter Technology CorpCommon Stock1442851032277,804SH SOLE 7,80400
Castle Biosciences IncCommon Stock14843C105138,9062,068,592SH SOLE 2,068,59200
Cellectis SAADR15117K103180,7366,679,077SH SOLE 6,137,609528,53612,932
Cerus CorpCommon Stock157085101204,64029,572,265SH SOLE 27,283,159616,2221,672,884
Codexis IncCommon Stock19200510686,4933,962,106SH SOLE 3,962,10600
Deere & CoCommon Stock24419910566,791248,248SH SOLE 248,24800
DuPont de Nemours IncCommon Stock26614N1021732,427SH SOLE 2,42700
Eastman Chemical CoCommon Stock2774321001681,673SH SOLE 1,67300
Editas Medicine IncCommon Stock28106W103709,90310,125,564SH SOLE 8,674,9051,008,363442,296
ExOne Co/TheCommon Stock30210410422,5422,375,334SH SOLE 1,994,5150380,819
FLIR Systems IncCommon Stock30244510164,5361,472,422SH SOLE 1,472,42200
Facebook IncCommon Stock30303M102178,733654,316SH SOLE 627,53126,7850
FARO Technologies IncCommon Stock3116421021,51821,492SH SOLE 21,49200
Fate Therapeutics IncCommon Stock31189P102263,8522,901,700SH SOLE 2,901,70000
General Electric CoCommon Stock3696041031,468135,928SH SOLE 135,92800
Grayscale Bitcoin Trust BTCOpen-End Fund389637109233,8317,307,228SH SOLE 6,171,965898,680236,583
Guardant Health IncCommon Stock40131M10969,664540,537SH SOLE 540,53700
Guidewire Software IncCommon Stock40171V10028,047217,878SH SOLE 217,87800
HDFC Bank LtdADR40415F10120,060277,611SH SOLE 277,61100
HP IncCommon Stock40434L1056,929281,788SH SOLE 281,78800
Hexcel CorpCommon Stock4282911081933,986SH SOLE 3,98600
HubSpot IncCommon Stock44357310056,790143,250SH SOLE 143,25000
Illumina IncCommon Stock45232710918,71650,585SH SOLE 050,5850
Incyte CorpCommon Stock45337C102155,0311,782,380SH SOLE 1,782,38000
Intellia Therapeutics IncCommon Stock45826J105608,82711,191,670SH SOLE 8,979,3071,384,498827,865
Interactive Brokers Group IncCommon Stock45841N1072514,113SH SOLE 4,11300
Intercontinental Exchange IncCommon Stock45866F104525,4894,557,974SH SOLE 4,193,764253,798110,412
Intuit IncCommon Stock46120210333,93389,333SH SOLE 89,33300
Intuitive Surgical IncCommon Stock46120E60221,16425,870SH SOLE 25,87000
OC Oerlikon Corp AGCommon StockH591871061,265122,093SH SOLE 122,09300
Invitae CorpCommon Stock46185L1031,128,91827,001,138SH SOLE 23,858,0132,155,092988,033
Ionis Pharmaceuticals IncCommon Stock462222100135,6712,399,554SH SOLE 2,399,55400
Iovance Biotherapeutics IncCommon Stock462260100709,81915,297,822SH SOLE 14,517,914466,145313,763
Iridium Communications IncCommon Stock46269C102274,1046,970,230SH SOLE 6,142,620560,242267,368
JD.com IncADR47215P106143,9611,637,783SH SOLE 1,637,78300
SGL Carbon SECommon StockD6949M10818541,875SH SOLE 41,87500
Kaiser Aluminum CorpCommon Stock4830077041,48114,970SH SOLE 14,97000
Komatsu LtdADR50045840141,2891,491,525SH SOLE 1,491,52500
Kratos Defense & Security SoluCommon Stock50077B20761,2662,233,535SH SOLE 2,233,53500
Henkel AG & Co KGaAPreferenceD3207M1101531,346SH SOLE 1,34600
Bertrandt AGCommon StockD1014N1071,22425,157SH SOLE 25,15700
LendingClub CorpCommon Stock52603A20878,7277,455,162SH SOLE 6,574,964183,369696,829
LendingTree IncCommon Stock52603B107550,3882,010,255SH SOLE 1,767,482160,89481,879
Dassault Systemes SECommon StockF2457H4725,18525,529SH SOLE 25,52900
Lincoln Electric Holdings IncCommon Stock5339001061,1059,506SH SOLE 9,50600
Siemens AGCommon StockD696712181,0637,358SH SOLE 7,35800
Materialise NVADR57667T100464,2598,564,081SH SOLE 8,257,63675,126231,319
MercadoLibre IncCommon Stock58733R102183,669109,639SH SOLE 100,2549,3850
Microsoft CorpCommon Stock5949181044,78021,490SH SOLE 21,49000
Bezeq The Israeli TelecommunicCommon StockM2012Q1001,3721,378,112SH SOLE 1,378,11200
Moog IncCommon Stock6153942021,15714,586SH SOLE 14,58600
Danel Adir Yeoshua LtdCommon StockM270131072,24013,601SH SOLE 13,60100
Hilan LtdCommon StockM5299H1231,81638,306SH SOLE 38,30600
Nano Dimension LtdADR63008G20376,3798,393,249SH SOLE 8,393,24900
NanoString Technologies IncCommon Stock63009R109261,9873,917,273SH SOLE 3,465,066447,0445,163
Elbit Systems LtdCommon StockM3760D10118,619142,345SH SOLE 142,34500
SBI Holdings Inc/JapanCommon StockJ6991H10054523,000SH SOLE 23,00000
Partner Communications Co LtdCommon StockM784651072,327422,156SH SOLE 422,15600
Netflix IncCommon Stock64110L106111,616206,418SH SOLE 204,5241,8940
Nice LtdADR6536561082,0097,084SH SOLE 7,08400
FirstRand LtdCommon StockS5202Z1313013,580SH SOLE 13,58000
NVIDIA CorpCommon Stock67066G10495,357182,606SH SOLE 175,6576,9490
NuVasive IncCommon Stock6707041051,00717,875SH SOLE 17,87500
Matrix IT LtdCommon StockM6859E1531,57069,419SH SOLE 69,41900
Toray Industries IncCommon StockJ8949411617028,708SH SOLE 28,70800
PTC IncCommon Stock69370C1006,43553,804SH SOLE 53,80400
Pacific Biosciences of CaliforCommon Stock69404D108739,41028,504,629SH SOLE 27,646,542413,947444,140
One Software Technologies LtdCommon StockM752601132,74120,737SH SOLE 20,73700
PayPal Holdings IncCommon Stock70450Y103605,3342,584,689SH SOLE 2,340,483190,69453,512
Personalis IncCommon Stock71535D106248,1656,778,623SH SOLE 6,778,62300
Straumann Holding AGCommon StockH8300N1195,9725,112SH SOLE 5,11200
Pinduoduo IncADR72230410232,405182,390SH SOLE 182,39000
Pinterest IncCommon Stock72352L106403,9536,129,780SH SOLE 5,156,525865,943107,312
Pluristem Therapeutics IncCommon Stock72940R30027,9933,959,344SH SOLE 3,959,34400
Proto Labs IncCommon Stock743713109631,9964,119,922SH SOLE 3,584,210346,687189,025
Redhill Biopharma LtdADR7574681031,347166,749SH SOLE 166,74900
Roku IncCommon Stock77543R1021,785,2125,376,822SH SOLE 4,706,975479,916189,931
salesforce.com IncCommon Stock79466L30249,691223,302SH SOLE 223,30200
Charles Schwab Corp/TheCommon Stock80851310525,788486,201SH SOLE 486,20100
Seres Therapeutics IncCommon Stock81750R102336,66113,741,254SH SOLE 12,097,7381,158,078485,438
Shopify IncCommon Stock82509L107544,582481,101SH SOLE 435,74834,17711,176
Snap IncCommon Stock83304A106166,4083,323,503SH SOLE 3,323,50300
Splunk IncCommon Stock848637104343,0542,019,273SH SOLE 1,781,886181,06756,320
Square IncCommon Stock8522341031,541,4167,082,410SH SOLE 6,294,595582,232205,583
Stryker CorpCommon Stock8636671011,0414,247SH SOLE 4,24700
Syros Pharmaceuticals IncCommon Stock87184Q10798,0989,041,321SH SOLE 8,237,117186,593617,611
Taiwan Semiconductor ManufactuADR874039100491,4864,507,394SH SOLE 3,956,306398,575152,513
Teladoc Health IncCommon Stock87918A1051,566,1537,832,332SH SOLE 7,209,660449,485173,187
Tencent Holdings LtdADR88032Q109454,5746,323,184SH SOLE 5,930,690301,40991,085
Teradyne IncCommon Stock88077010228,539238,047SH SOLE 238,04700
Tesla IncCommon Stock88160R1012,917,3994,134,226SH SOLE 3,778,990350,0365,200
Teva Pharmaceutical IndustriesADR8816242091,735179,802SH SOLE 179,80200
Trade Desk Inc/TheCommon Stock88339J10565,34881,583SH SOLE 81,58300
3D Systems CorpCommon Stock88554D2058,581818,772SH SOLE 818,77200
3M CoCommon Stock88579Y101148845SH SOLE 84500
Trimble IncCommon Stock89623910074,7781,119,940SH SOLE 1,119,94000
Twilio IncCommon Stock90138F102607,1871,793,759SH SOLE 1,588,760156,49148,508
Twist Bioscience CorpCommon Stock90184D100830,3575,876,971SH SOLE 5,570,693139,968166,310
2U IncCommon Stock90214J101530,59613,261,577SH SOLE 11,265,3011,396,560599,716
Ultra Clean Holdings IncCommon Stock90385V1071,22239,220SH SOLE 39,22000
United Parcel Service IncCommon Stock9113121069325,536SH SOLE 5,53600
Veracyte IncCommon Stock92337F107441,8229,027,827SH SOLE 8,814,751213,0760
Verisk Analytics IncCommon Stock92345Y10616,13377,714SH SOLE 77,71400
Workday IncCommon Stock98138H10139,845166,290SH SOLE 166,29000
Xilinx IncCommon Stock98391910129,107205,309SH SOLE 164,09741,2120
Xerox Holdings CorpCommon Stock98421M1061677,200SH SOLE 7,20000
Zillow Group IncCommon Stock98954M200841,2606,481,205SH SOLE 5,714,512571,735194,958
Koninklijke DSM NVCommon StockN5017D122145843SH SOLE 84300
Arkema SACommon StockF0392W1251481,294SH SOLE 1,29400
MGI Digital Graphic TechnologyCommon StockF4090S1135,82799,824SH SOLE 99,82400
Sandvik ABCommon StockW748571651827,402SH SOLE 7,40200
Hexagon ABCommon StockW400631041,65518,090SH SOLE 18,09000
Cellcom Israel LtdCommon StockM2196U1092,106427,345SH SOLE 427,34500
Evonik Industries AGCommon StockD2R90Y1171755,337SH SOLE 5,33700
Fattal Holdings 1998 LtdCommon StockM4148G1052,70425,141SH SOLE 25,14100
MeituanCommon StockG5966910454,1361,424,815SH SOLE 1,424,81500
SLM Solutions Group AGCommon StockD6T6901099,083424,298SH SOLE 424,29800
ZhongAn Online P&C Insurance CCommon StockY989DF10936,0847,728,745SH SOLE 7,728,74500
Adyen NVCommon StockN3501V10473,67131,634SH SOLE 31,63400
Atlassian Corp PLCCommon StockG0624210451,296219,336SH SOLE 219,33600
Medtronic PLCCommon StockG5960L1031,0338,819SH SOLE 8,81900
Sapiens International Corp NVCommon StockG7T16G1031,67754,784SH SOLE 54,78400
CRISPR Therapeutics AGCommon StockH171821081,594,33110,412,976SH SOLE 9,317,964741,603353,409
Spotify Technology SACommon StockL8681T102741,4452,356,336SH SOLE 2,082,876197,85575,605
Allot LtdCommon StockM0854Q1051,732164,625SH SOLE 164,62500
AudioCodes LtdCommon StockM153421041,38050,074SH SOLE 50,07400
Camtek Ltd/IsraelCommon StockM207911052,00391,434SH SOLE 91,43400
Ceragon Networks LtdCommon StockM220131021,816653,123SH SOLE 653,12300
Check Point Software TechnologCommon StockM224651041,74013,093SH SOLE 13,09300
Compugen LtdCommon StockM25722105206,87917,083,306SH SOLE 16,714,552219,844148,910
CyberArk Software LtdCommon StockM2682V1082,41114,918SH SOLE 14,91800
Evogene LtdCommon StockM4119S10421,5944,594,499SH SOLE 4,594,49900
Fiverr International LtdCommon StockM4R82T1062,03010,406SH SOLE 10,40600
Ituran Location and Control LtCommon StockM6158M1042,271119,194SH SOLE 119,19400
Nova Measuring Instruments LtdCommon StockM7516K1032,04128,913SH SOLE 28,91300
Radware LtdCommon StockM818731071,89368,213SH SOLE 68,21300
Stratasys LtdCommon StockM85548101250,45612,087,661SH SOLE 9,346,9181,389,7001,351,043
Taro Pharmaceutical IndustriesCommon StockM8737E1082,05728,021SH SOLE 28,02100
Tower Semiconductor LtdCommon StockM879152742,18684,677SH SOLE 84,67700
UroGen Pharma LtdCommon StockM960881051,32973,769SH SOLE 73,76900
Wix.com LtdCommon StockM980681051,4625,848SH SOLE 5,84800
NXP Semiconductors NVCommon StockN6596X10951,938326,634SH SOLE 326,63400
DocuSign IncCommon Stock256163106484,6192,180,021SH SOLE 2,054,41085,71639,895
Zscaler IncCommon Stock98980G1029,86249,382SH SOLE 62148,7610
GMO internet IncCommon StockJ1822R10424800SH SOLE 80000
Discovery LtdCommon StockS2192Y10923,9202,285,684SH SOLE 2,285,68400
Inmode LtdCommon StockM5425M1031,96141,303SH SOLE 41,30300
Perion Network LtdCommon StockM786731142,774217,906SH SOLE 217,90600
Silvergate Capital CorpCommon Stock82837P40846,874630,789SH SOLE 630,78900
MeituanADR58533E1032313,080SH SOLE 3,08000
Z Holdings CorpCommon StockJ9894K10537,9306,272,007SH SOLE 6,272,00700
Sea LtdADR81141R100383,6631,927,472SH SOLE 1,781,856105,06740,549
Z Holdings CorpADR98877X10160650,017SH SOLE 50,01700
Pure Storage IncCommon Stock74624M102930,65641,161,248SH SOLE 37,511,2552,624,5701,025,423
Synopsys IncCommon Stock871607107264,7311,021,182SH SOLE 962,85432,82225,506
HUYA IncADR44852D108231,20811,600,993SH SOLE 10,642,894620,710337,389
RADA Electronic Industries LtdCommon StockM818631242,441250,312SH SOLE 250,31200
PagerDuty IncCommon Stock69553P100481,54511,547,833SH SOLE 9,992,0001,044,146511,687
Caterpillar IncCommon Stock14912310145,433249,604SH SOLE 249,60400
Rockwell Automation IncCommon Stock77390310914,01155,862SH SOLE 55,86200
Arconic CorpCommon Stock03966V1071,24041,618SH SOLE 41,61800
Lightspeed POS IncCommon Stock53227R10646,466660,370SH SOLE 660,37000
Adaptive Biotechnologies CorpCommon Stock00650F10991,3971,545,703SH SOLE 1,545,70300
10X Genomics IncCommon Stock88025U10975,543533,496SH SOLE 533,49600
Crowdstrike Holdings IncCommon Stock22788C10554,438257,002SH SOLE 257,00200
Okta IncCommon Stock67929510546,491182,849SH SOLE 182,84900
Bitcoin Fund/TheClosed-End Fund09175G10411,810313,436SH SOLE 00313,436
Schrodinger Inc/United StatesCommon Stock80810D103110,4921,395,453SH SOLE 1,395,45300
Slack Technologies IncCommon Stock83088V10246,7381,106,491SH SOLE 17,0271,089,4640
TCS Group Holding PLCGDR87238U20321,861664,465SH SOLE 664,46500
Phreesia IncCommon Stock71944F10671,4331,316,496SH SOLE 1,316,49600
Virgin Galactic Holdings IncCommon Stock92766K10631,9361,345,793SH SOLE 1,345,79300
Workhorse Group IncCommon Stock98138J20636,5581,848,216SH SOLE 1,848,21600
Adyen NVADR00783V10453,1031,144,465SH SOLE 1,144,46500
Cie Generale des EtablissementCommon StockF618241441,1358,850SH SOLE 8,85000
voestalpine AGCommon StockA9101Y1031855,126SH SOLE 5,12600
Yeahka LtdCommon StockG9835C10820,4174,210,400SH SOLE 4,210,40000
Accolade IncCommon Stock00437E102103,0212,368,304SH SOLE 2,368,30400
Berkeley Lights IncCommon Stock084310101130,9421,464,517SH SOLE 1,464,51700
Vertex Pharmaceuticals IncCommon Stock92532F100192,899816,194SH SOLE 816,19400
BYD Co LtdADR05606L10045,616864,427SH SOLE 864,42700
Ayala Pharmaceuticals IncCommon Stock05465V1081,248113,450SH SOLE 113,45000
Biondvax Pharmaceuticals LtdADR09073Q10511741,566SH SOLE 41,56600
Kamada LtdCommon StockM6240T1091,349209,833SH SOLE 209,83300
BATM Advanced Communications LCommon StockM191991121,4061,112,971SH SOLE 1,112,97100
Gamida Cell LtdCommon StockM473641002,702322,026SH SOLE 322,02600
Gilat Satellite Networks LtdCommon StockM514741182,168332,564SH SOLE 332,56400
PolyPid LtdCommon StockM8001Q1181,423143,728SH SOLE 143,72800
Silicom LtdCommon StockM841161081,96446,930SH SOLE 46,93000
Nintendo Co LtdADR654445303355,8284,419,131SH SOLE 3,927,962363,970127,199
Organovo Holdings IncCommon Stock68620A20317,2771,404,620SH SOLE 1,401,0923,5280
Surface Oncology IncCommon Stock86877M20923,4922,542,391SH SOLE 2,542,39100
Takeda Pharmaceutical Co LtdADR874060205156,8518,618,165SH SOLE 8,618,16500
Niu TechnologiesADR65481N10024,899887,653SH SOLE 887,65300
Thermo Fisher Scientific IncCommon Stock88355610288,623190,269SH SOLE 190,26900
Exact Sciences CorpCommon Stock30063P105703,8495,312,466SH SOLE 4,786,293406,610119,563
ARK Innovation ETFETP00214Q1043632,914SH SOLE 2,91400
Siemens Energy AGCommon StockD6T47E106374SH SOLE 7400
Snowflake IncCommon Stock8334451092898SH SOLE 9800
Unity Software IncCommon Stock91332U101365,4652,381,348SH SOLE 2,224,74884,90071,700
Beam Therapeutics IncCommon Stock07373V10592,3861,131,623SH SOLE 1,131,62300
Novartis AGCommon StockH5820Q150201,7782,129,945SH SOLE 2,129,94500
Regeneron Pharmaceuticals IncCommon Stock75886F107218,278451,818SH SOLE 451,81800
Repare Therapeutics IncCommon Stock76027310221,794635,393SH SOLE 635,39300
MarketAxess Holdings IncCommon Stock57060D1089,61216,846SH SOLE 16,84600
Agora IncADR00851L10362,1051,569,888SH SOLE 1,569,88800
KE Holdings IncADR482497104408,5086,638,093SH SOLE 5,983,017475,448179,628
Fastly IncCommon Stock31188V10099,4841,138,656SH SOLE 1,138,65600
Cloudflare IncCommon Stock18915M10755,088724,940SH SOLE 724,94000
Palantir Technologies IncCommon Stock69608A10831,0181,317,122SH SOLE 1,317,12200
Raven Industries IncCommon Stock75421210816,338493,743SH SOLE 493,74300
Zoom Video Communications IncCommon Stock98980L101322,165955,071SH SOLE 887,56837,97329,530
Longview Acquisition CorpCommon Stock54319510129,8341,507,542SH SOLE 1,507,54200
Honeywell International IncCommon Stock4385161067,97137,476SH SOLE 37,47600
Alphabet IncCommon Stock02079K305164,94194,110SH SOLE 94,11000
Roche Holding AGADR771195104234,8515,357,003SH SOLE 5,357,00300
ARK Genomic Revolution ETFETP00214Q3021561,670SH SOLE 1,67000
Sarepta Therapeutics IncCommon Stock80360710041,414242,911SH SOLE 242,91100
Opendoor Technologies IncCommon Stock68371210390,9484,001,226SH SOLE 4,001,22600
BASE IncCommon StockJ0433G10120,721219,200SH SOLE 219,20000
Kaspi.KZ JSCGDR48581R2052,58738,548SH SOLE 38,54800
JD Health International IncCommon StockG5074A1001346,925SH SOLE 6,92500
salesforce.com IncCommon Stock79466L30249,691223,302SH SOLE 223,30200
908 Devices IncCommon Stock65443P10224,901437,248SH SOLE 437,24800
Magna International IncCommon Stock5592224018,304117,282SH SOLE 117,28200
Peloton Interactive IncCommon Stock70614W10066,936441,179SH SOLE 441,17900
Veeva Systems IncCommon Stock92247510882,391302,629SH SOLE 302,62900