<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001697652</cik>
        <entityName>Schroder Adveq Europe Direct II S.C.S.</entityName>
        <issuerAddress>
            <street1>6C, Rue Gabriel Lippmann</street1>
            <city>Munsbach</city>
            <stateOrCountry>N4</stateOrCountry>
            <stateOrCountryDescription>LUXEMBOURG</stateOrCountryDescription>
            <zipCode>L-5365</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>41 58 445 55 55</issuerPhoneNumber>
        <jurisdictionOfInc>LUXEMBOURG</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>Adveq Europe Direct II S.C.S.</previousName>
        </edgarPreviousNameList>
        <entityType>Limited Partnership</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2016</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>N/A</firstName>
                <lastName>SCHRODER ADVEQ MANAGEMENT LUXEMBOURG S.A.R.L.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>6C, rue Gabriel Lippmann</street1>
                <city>Munsbach</city>
                <stateOrCountry>N4</stateOrCountry>
                <stateOrCountryDescription>LUXEMBOURG</stateOrCountryDescription>
                <zipCode>L-5365</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>General Partner of the Issuer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>N/A</firstName>
                <lastName>SCHRODER ADVEQ MANAGEMENT AG</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>AFFOLTERNSTRASSE 56</street1>
                <city>ZURICH</city>
                <stateOrCountry>V8</stateOrCountry>
                <stateOrCountryDescription>SWITZERLAND</stateOrCountryDescription>
                <zipCode>CH-8050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Investment Manager of the Issuer (the &quot;Investment Manager&quot;)</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>PETER</firstName>
                <lastName>ARNOLD</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>AFFOLTERNSTRASSE 56</street1>
                <city>ZURICH</city>
                <stateOrCountry>V8</stateOrCountry>
                <stateOrCountryDescription>SWITZERLAND</stateOrCountryDescription>
                <zipCode>CH-8050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Member of the Investment Manager's Management Committee</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>RAINER</firstName>
                <lastName>ENDER</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>AFFOLTERNSTRASSE 56</street1>
                <city>ZURICH</city>
                <stateOrCountry>V8</stateOrCountry>
                <stateOrCountryDescription>SWITZERLAND</stateOrCountryDescription>
                <zipCode>CH-8050</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Member of the Investment Manager's Management Committee</relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pooled Investment Fund</industryGroupType>
            <investmentFundInfo>
                <investmentFundType>Private Equity Fund</investmentFundType>
                <is40Act>false</is40Act>
            </investmentFundInfo>
        </industryGroup>
        <issuerSize>
            <revenueRange>Not Applicable</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
            <item>3C</item>
            <item>3C.7</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001697652-17-000005</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2018-06-06</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isPooledInvestmentFundType>true</isPooledInvestmentFundType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Schroder Fund Advisors LLC</recipientName>
                <recipientCRDNumber>24129</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>7 Byrant Park</street1>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10018</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>550000000</totalOfferingAmount>
            <totalAmountSold>220660000</totalAmountSold>
            <totalRemaining>329340000</totalRemaining>
            <clarificationOfResponse>Conversion rate USD 1.10 to Euro 1 at 1/29/2020. Total Offering Amount reflects the parallel offerings to US and non-US persons.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>14</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>The Issuer's General Partner or its designee will generally receive a fee at an annual rate as a percentage of each investor's subscription to the Issuer, as specified in the Issuer's partnership agreement.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Schroder Adveq Europe Direct II S.C.S.</issuerName>
                <signatureName>/s/ Yves Cheret</signatureName>
                <nameOfSigner>Yves Cheret</nameOfSigner>
                <signatureTitle>Manager of the applicant's General Partner</signatureTitle>
                <signatureDate>2020-01-29</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
