X0508 4 2025-06-05 0 0001781983 Aprea Therapeutics, Inc. APRE 0001697628 Peters Richard 3805 OLD EASTON ROAD DOYLESTOWN PA 18902 1 0 0 0 0 Common Stock 2025-06-05 4 A 0 1045 0.00 A 3119 D Stock Options (Right to Buy) 1.81 2025-06-05 4 A 0 4185 0.00 A 2035-06-05 Common Stock 4185 4185 D These shares represent restricted stock units which were granted on June 5, 2025, and which will vest and be settled in common stock on June 5, 2026, subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions. The option vests in full on June 5, 2026, subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions. /s/ John Hamill, as Attorney-in-Fact 2025-06-09