X0306 4 2020-06-26 0001781983 Aprea Therapeutics, Inc. APRE 0001697628 Peters Richard 535 BOYLSTON STREET BOSTON MA 02116 true Stock Option (right to Buy) 38.32 2020-06-26 4 A 0 7000 0 A 2030-06-26 Common Stock 7000 7000 D The option vests in three equal annual installments beginning on June 26, 2021 subject to the reporting person's continued service on the Issuer's board of directors through and including the applicable vesting date and subject to acceleration under certain conditions. /s/ Scott M. Coiante, attorney-in-fact 2020-06-29