SCHEDULE 13G/A 0002012383 XXXXXXXX LIVE 2 Common Stock 06/30/2025 0001697532 APPLIED THERAPEUTICS INC. 03828A101 545 FIFTH AVENUE, SUITE 1400 NEW YORK NY 10017 Rule 13d-1(b) BlackRock, Inc. b DE 5195137 0 5219475 0 5219475 3.7 HC APPLIED THERAPEUTICS INC. 545 FIFTH AVENUE, SUITE 1400 NEW YORK NY 10017 BlackRock, Inc. In accordance with SEC Release No. 34-39538 (January 12, 1998), this Schedule 13G reflects the securities beneficially owned, or deemed to be beneficially owned, by certain business units (collectively, the "Reporting Business Units") of BlackRock, Inc. and its subsidiaries and affiliates. It does not include securities, if any, beneficially owned by other business units whose beneficial ownership of securities are disaggregated from that of the Reporting Business Units in accordance with such release. BlackRock, Inc., 50 Hudson Yards New York, NY 10001 See Item 4 of Cover Page N HC 5219475 3.7 5195137 0 5219475 0 N Y N Various persons have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of the common stock of APPLIED THERAPEUTICS INC.. No one person's interest in the common stock of APPLIED THERAPEUTICS INC. is more than five percent of the total outstanding common shares. N See Exhibit 99 Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 24: Power of Attorney Exhibit 99: Item 7 BlackRock, Inc. Spencer Fleming 07/16/2025