X0508 4 2023-11-20 0 0001697532 Applied Therapeutics Inc. APLT 0001775394 Funtleyder Leslie D. C/O APPLIED THERAPEUTICS, INC. 545 FIFTH AVENUE, SUITE 1400 NEW YORK NY 10017 1 1 0 0 Chief Financial Officer 0 Common Stock 2023-11-20 4 A 0 300000 0.00 A 337148 D Consists of compensatory Restricted Stock Units granted under Applied Therapeutics, Inc.'s 2019 Equity Incentive Plan in connection with the Reporting Person's appointment as Chief Financial Officer. Each compensatory Restricted Stock Unit represents a contingent right to receive one share of the issuer's common stock. The compensatory Restricted Stock Units shall vest in equal monthly installments over the two-year period following the date of grant, subject to the Reporting Person continuing to provide services through each such vesting date. /s/ Shoshana Shendelman, as attorney-in-fact 2023-11-20